Septic patients in the intensive care unit present different nasal microbiotas

AIM: The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS: A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS: The nasal microbiota i...

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Detalles Bibliográficos
Autores principales: Tan, Xi-lan, Liu, Hai-yue, Long, Jun, Jiang, Zhaofang, Luo, Yuemei, Zhao, Xin, Cai, Shumin, Zhong, Xiaozhu, Cen, Zhongran, Su, Jin, Zhou, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479279/
https://www.ncbi.nlm.nih.gov/pubmed/30803270
http://dx.doi.org/10.2217/fmb-2018-0349
Descripción
Sumario:AIM: The primary objective of this study was to evaluate correlations among mortality, intensive care unit (ICU) length of stay and airway microbiotas in septic patients. MATERIALS & METHODS: A deep-sequencing analysis of the 16S rRNA gene V4 region was performed. RESULTS: The nasal microbiota in septic patients was dominated by three nasal bacterial types (Corynebacterium, Staphylococcus and Acinetobacter). The Acinetobacter type was associated with the lowest diversity and longest length of stay (median: 9 days), and the Corynebacterium type was associated with the shortest length of stay. We found that the Acinetobacter type in the >9-day group was associated with the highest mortality (33%). CONCLUSION: Septic patients have three nasal microbiota types, and the nasal microbiota is related to the length of stay and mortality.

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