Quantitative Analysis of Tozadenant Using Liquid Chromatography-Mass Spectrometric Method in Rat Plasma and Its Human Pharmacokinetics Prediction Using Physiologically Based Pharmacokinetic Modeling

Tozadenant is one of the selective adenosine A2a receptor antagonists with a potential to be a new Parkinson’s disease (PD) therapeutic drug. In this study, a liquid chromatography-mass spectrometry based bioanalytical method was qualified and applied for the quantitative analysis of tozadenant in r...

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Detalles Bibliográficos
Autores principales: Lee, Byeong ill, Park, Min-Ho, Shin, Seok-Ho, Byeon, Jin-Ju, Park, Yuri, Kim, Nahye, Choi, Jangmi, Shin, Young G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479388/
https://www.ncbi.nlm.nih.gov/pubmed/30987056
http://dx.doi.org/10.3390/molecules24071295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479388/
https://www.ncbi.nlm.nih.gov/pubmed/30987056
http://dx.doi.org/10.3390/molecules24071295

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