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Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature
Melkersson–Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 publis...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479526/ https://www.ncbi.nlm.nih.gov/pubmed/30974872 http://dx.doi.org/10.3390/ijerph16071289 |
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author | Savasta, Salvatore Rossi, Alessandra Foiadelli, Thomas Licari, Amelia Elena Perini, Anna Maria Farello, Giovanni Verrotti, Alberto Marseglia, Gian Luigi |
author_facet | Savasta, Salvatore Rossi, Alessandra Foiadelli, Thomas Licari, Amelia Elena Perini, Anna Maria Farello, Giovanni Verrotti, Alberto Marseglia, Gian Luigi |
author_sort | Savasta, Salvatore |
collection | PubMed |
description | Melkersson–Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 published patients. The aetiology of this disease is still unclear. However, genetic factors, as well as alterations in immune functions, infections, and allergic reactions have been postulated. We report three children suffering from MRS and perform a literature review of paediatric cases. Taking into account that clinical and laboratoristical criteria for the diagnosis of MRS are lacking, this syndrome is probably underestimated, and we suggest increasing awareness of such a rare syndrome. Close multidisciplinary follow-up of these children with a team composed by paediatricians, neurologists, neuro-ophthalmologists, dermatologists, and otolaryngologists is crucial to guarantee exhaustive management and treatment success, while minimising relapses. |
format | Online Article Text |
id | pubmed-6479526 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64795262019-04-29 Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature Savasta, Salvatore Rossi, Alessandra Foiadelli, Thomas Licari, Amelia Elena Perini, Anna Maria Farello, Giovanni Verrotti, Alberto Marseglia, Gian Luigi Int J Environ Res Public Health Case Report Melkersson–Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 published patients. The aetiology of this disease is still unclear. However, genetic factors, as well as alterations in immune functions, infections, and allergic reactions have been postulated. We report three children suffering from MRS and perform a literature review of paediatric cases. Taking into account that clinical and laboratoristical criteria for the diagnosis of MRS are lacking, this syndrome is probably underestimated, and we suggest increasing awareness of such a rare syndrome. Close multidisciplinary follow-up of these children with a team composed by paediatricians, neurologists, neuro-ophthalmologists, dermatologists, and otolaryngologists is crucial to guarantee exhaustive management and treatment success, while minimising relapses. MDPI 2019-04-10 2019-04 /pmc/articles/PMC6479526/ /pubmed/30974872 http://dx.doi.org/10.3390/ijerph16071289 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Savasta, Salvatore Rossi, Alessandra Foiadelli, Thomas Licari, Amelia Elena Perini, Anna Maria Farello, Giovanni Verrotti, Alberto Marseglia, Gian Luigi Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature |
title | Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature |
title_full | Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature |
title_fullStr | Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature |
title_full_unstemmed | Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature |
title_short | Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature |
title_sort | melkersson–rosenthal syndrome in childhood: report of three paediatric cases and a review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479526/ https://www.ncbi.nlm.nih.gov/pubmed/30974872 http://dx.doi.org/10.3390/ijerph16071289 |
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