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Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature

Melkersson–Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 publis...

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Autores principales: Savasta, Salvatore, Rossi, Alessandra, Foiadelli, Thomas, Licari, Amelia, Elena Perini, Anna Maria, Farello, Giovanni, Verrotti, Alberto, Marseglia, Gian Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479526/
https://www.ncbi.nlm.nih.gov/pubmed/30974872
http://dx.doi.org/10.3390/ijerph16071289
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author Savasta, Salvatore
Rossi, Alessandra
Foiadelli, Thomas
Licari, Amelia
Elena Perini, Anna Maria
Farello, Giovanni
Verrotti, Alberto
Marseglia, Gian Luigi
author_facet Savasta, Salvatore
Rossi, Alessandra
Foiadelli, Thomas
Licari, Amelia
Elena Perini, Anna Maria
Farello, Giovanni
Verrotti, Alberto
Marseglia, Gian Luigi
author_sort Savasta, Salvatore
collection PubMed
description Melkersson–Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 published patients. The aetiology of this disease is still unclear. However, genetic factors, as well as alterations in immune functions, infections, and allergic reactions have been postulated. We report three children suffering from MRS and perform a literature review of paediatric cases. Taking into account that clinical and laboratoristical criteria for the diagnosis of MRS are lacking, this syndrome is probably underestimated, and we suggest increasing awareness of such a rare syndrome. Close multidisciplinary follow-up of these children with a team composed by paediatricians, neurologists, neuro-ophthalmologists, dermatologists, and otolaryngologists is crucial to guarantee exhaustive management and treatment success, while minimising relapses.
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spelling pubmed-64795262019-04-29 Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature Savasta, Salvatore Rossi, Alessandra Foiadelli, Thomas Licari, Amelia Elena Perini, Anna Maria Farello, Giovanni Verrotti, Alberto Marseglia, Gian Luigi Int J Environ Res Public Health Case Report Melkersson–Rosenthal syndrome (MRS) in children is a rare condition, clinically characterised by a triad of synchronous or metachronous symptoms: recurrent peripheral facial palsy, relapsing orofacial oedema, and a fissured tongue; the most recent review published on the topic has reported 30 published patients. The aetiology of this disease is still unclear. However, genetic factors, as well as alterations in immune functions, infections, and allergic reactions have been postulated. We report three children suffering from MRS and perform a literature review of paediatric cases. Taking into account that clinical and laboratoristical criteria for the diagnosis of MRS are lacking, this syndrome is probably underestimated, and we suggest increasing awareness of such a rare syndrome. Close multidisciplinary follow-up of these children with a team composed by paediatricians, neurologists, neuro-ophthalmologists, dermatologists, and otolaryngologists is crucial to guarantee exhaustive management and treatment success, while minimising relapses. MDPI 2019-04-10 2019-04 /pmc/articles/PMC6479526/ /pubmed/30974872 http://dx.doi.org/10.3390/ijerph16071289 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Savasta, Salvatore
Rossi, Alessandra
Foiadelli, Thomas
Licari, Amelia
Elena Perini, Anna Maria
Farello, Giovanni
Verrotti, Alberto
Marseglia, Gian Luigi
Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature
title Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature
title_full Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature
title_fullStr Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature
title_full_unstemmed Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature
title_short Melkersson–Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature
title_sort melkersson–rosenthal syndrome in childhood: report of three paediatric cases and a review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479526/
https://www.ncbi.nlm.nih.gov/pubmed/30974872
http://dx.doi.org/10.3390/ijerph16071289
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