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The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice
Atherosclerosis and nonalcoholic fatty liver disease (NAFLD) are frequent causes of death in the Western countries. Recently, it has been shown that autophagy dysfunction plays an important role in the pathogenesis of both atherosclerosis and NAFLD; thus, activators of autophagy might be useful for...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479548/ https://www.ncbi.nlm.nih.gov/pubmed/30925684 http://dx.doi.org/10.3390/ijms20071552 |
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author | Stachowicz, Aneta Wiśniewska, Anna Kuś, Katarzyna Kiepura, Anna Gębska, Anna Gajda, Mariusz Białas, Magdalena Totoń-Żurańska, Justyna Stachyra, Kamila Suski, Maciej Jawień, Jacek Korbut, Ryszard Olszanecki, Rafał |
author_facet | Stachowicz, Aneta Wiśniewska, Anna Kuś, Katarzyna Kiepura, Anna Gębska, Anna Gajda, Mariusz Białas, Magdalena Totoń-Żurańska, Justyna Stachyra, Kamila Suski, Maciej Jawień, Jacek Korbut, Ryszard Olszanecki, Rafał |
author_sort | Stachowicz, Aneta |
collection | PubMed |
description | Atherosclerosis and nonalcoholic fatty liver disease (NAFLD) are frequent causes of death in the Western countries. Recently, it has been shown that autophagy dysfunction plays an important role in the pathogenesis of both atherosclerosis and NAFLD; thus, activators of autophagy might be useful for novel therapeutic interventions. Trehalose—a naturally occuring disaccharide present in plants, bacteria, fungi, insects, and certain types of shrimps—is a known inducer of autophagy. However, according to the literature, its anti-atherosclerotic and anti-steatotic potential seem to depend on the experimental setting. The aim of our study was to comprehensively describe the influence of a prolonged treatment with orally administered trehalose on the development of atherosclerotic lesions and hepatic steatosis in apolipoprotein E knockout (apoE(−/−)) mice in an experimental set up reflecting both moderate and severe proatherogenic conditions: male apoE(−/−) mice on a chow diet (CD) and female apoE(−/−) mice fed with a high-fat diet (HFD). We found that exogenous trehalose inhibited atherosclerosis and attenuated hepatic steatosis in apoE(−/−) mice. Such effects of trehalose were not associated with changes of plasma cholesterol, low-density lipoproteins (LDL), or high-density lipoproteins (HDL). Moreover, the anti-steatotic action of trehalose in the liver was associated with the induction of autophagy. The exact molecular mechanisms of both the anti-atherosclerotic action of trehalose and its inhibitory effect on liver steatosis require further clarification. |
format | Online Article Text |
id | pubmed-6479548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64795482019-04-29 The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice Stachowicz, Aneta Wiśniewska, Anna Kuś, Katarzyna Kiepura, Anna Gębska, Anna Gajda, Mariusz Białas, Magdalena Totoń-Żurańska, Justyna Stachyra, Kamila Suski, Maciej Jawień, Jacek Korbut, Ryszard Olszanecki, Rafał Int J Mol Sci Article Atherosclerosis and nonalcoholic fatty liver disease (NAFLD) are frequent causes of death in the Western countries. Recently, it has been shown that autophagy dysfunction plays an important role in the pathogenesis of both atherosclerosis and NAFLD; thus, activators of autophagy might be useful for novel therapeutic interventions. Trehalose—a naturally occuring disaccharide present in plants, bacteria, fungi, insects, and certain types of shrimps—is a known inducer of autophagy. However, according to the literature, its anti-atherosclerotic and anti-steatotic potential seem to depend on the experimental setting. The aim of our study was to comprehensively describe the influence of a prolonged treatment with orally administered trehalose on the development of atherosclerotic lesions and hepatic steatosis in apolipoprotein E knockout (apoE(−/−)) mice in an experimental set up reflecting both moderate and severe proatherogenic conditions: male apoE(−/−) mice on a chow diet (CD) and female apoE(−/−) mice fed with a high-fat diet (HFD). We found that exogenous trehalose inhibited atherosclerosis and attenuated hepatic steatosis in apoE(−/−) mice. Such effects of trehalose were not associated with changes of plasma cholesterol, low-density lipoproteins (LDL), or high-density lipoproteins (HDL). Moreover, the anti-steatotic action of trehalose in the liver was associated with the induction of autophagy. The exact molecular mechanisms of both the anti-atherosclerotic action of trehalose and its inhibitory effect on liver steatosis require further clarification. MDPI 2019-03-28 /pmc/articles/PMC6479548/ /pubmed/30925684 http://dx.doi.org/10.3390/ijms20071552 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Stachowicz, Aneta Wiśniewska, Anna Kuś, Katarzyna Kiepura, Anna Gębska, Anna Gajda, Mariusz Białas, Magdalena Totoń-Żurańska, Justyna Stachyra, Kamila Suski, Maciej Jawień, Jacek Korbut, Ryszard Olszanecki, Rafał The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice |
title | The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice |
title_full | The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice |
title_fullStr | The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice |
title_full_unstemmed | The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice |
title_short | The Influence of Trehalose on Atherosclerosis and Hepatic Steatosis in Apolipoprotein E Knockout Mice |
title_sort | influence of trehalose on atherosclerosis and hepatic steatosis in apolipoprotein e knockout mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479548/ https://www.ncbi.nlm.nih.gov/pubmed/30925684 http://dx.doi.org/10.3390/ijms20071552 |
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