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Ion Channels Involved in Substance P-Mediated Nociception and Antinociception
Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of pain. However, accumulating studies have proposed a paradoxical role of SP in anti-nociception. Here, we review studies of SP-mediated nociception and anti-nociception in terms of peptide features, SP-modulated...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479580/ https://www.ncbi.nlm.nih.gov/pubmed/30935032 http://dx.doi.org/10.3390/ijms20071596 |
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author | Chang, Chu-Ting Jiang, Bo-Yang Chen, Chih-Cheng |
author_facet | Chang, Chu-Ting Jiang, Bo-Yang Chen, Chih-Cheng |
author_sort | Chang, Chu-Ting |
collection | PubMed |
description | Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of pain. However, accumulating studies have proposed a paradoxical role of SP in anti-nociception. Here, we review studies of SP-mediated nociception and anti-nociception in terms of peptide features, SP-modulated ion channels, and differential effector systems underlying neurokinin 1 receptors (NK1Rs) in differential cell types to elucidate the effect of SP and further our understanding of SP in anti-nociception. Most importantly, understanding the anti-nociceptive SP-NK1R pathway would provide new insights for analgesic drug development. |
format | Online Article Text |
id | pubmed-6479580 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64795802019-04-29 Ion Channels Involved in Substance P-Mediated Nociception and Antinociception Chang, Chu-Ting Jiang, Bo-Yang Chen, Chih-Cheng Int J Mol Sci Review Substance P (SP), an 11-amino-acid neuropeptide, has long been considered an effector of pain. However, accumulating studies have proposed a paradoxical role of SP in anti-nociception. Here, we review studies of SP-mediated nociception and anti-nociception in terms of peptide features, SP-modulated ion channels, and differential effector systems underlying neurokinin 1 receptors (NK1Rs) in differential cell types to elucidate the effect of SP and further our understanding of SP in anti-nociception. Most importantly, understanding the anti-nociceptive SP-NK1R pathway would provide new insights for analgesic drug development. MDPI 2019-03-30 /pmc/articles/PMC6479580/ /pubmed/30935032 http://dx.doi.org/10.3390/ijms20071596 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chang, Chu-Ting Jiang, Bo-Yang Chen, Chih-Cheng Ion Channels Involved in Substance P-Mediated Nociception and Antinociception |
title | Ion Channels Involved in Substance P-Mediated Nociception and Antinociception |
title_full | Ion Channels Involved in Substance P-Mediated Nociception and Antinociception |
title_fullStr | Ion Channels Involved in Substance P-Mediated Nociception and Antinociception |
title_full_unstemmed | Ion Channels Involved in Substance P-Mediated Nociception and Antinociception |
title_short | Ion Channels Involved in Substance P-Mediated Nociception and Antinociception |
title_sort | ion channels involved in substance p-mediated nociception and antinociception |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479580/ https://www.ncbi.nlm.nih.gov/pubmed/30935032 http://dx.doi.org/10.3390/ijms20071596 |
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