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Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation

OBJECTIVE: The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the transition to hepatocellular carcinoma (HCC). Previous work showed endogenous glucose production is reduced in GNMT-null mice with gluconeogenic precursors being used in alternative biosynthetic pathways...

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Detalles Bibliográficos
Autores principales:	Hughey, Curtis C., James, Freyja D., Wang, Zhizhang, Goelzer, Mickael, Wasserman, David H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479583/ https://www.ncbi.nlm.nih.gov/pubmed/30850319 http://dx.doi.org/10.1016/j.molmet.2019.02.006

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