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Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment

An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (...

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Autores principales: Tuminello, Stephanie, van Gerwen, Maaike A. G., Genden, Eric, Crane, Michael, Lieberman-Cribbin, Wil, Taioli, Emanuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479621/
https://www.ncbi.nlm.nih.gov/pubmed/30970543
http://dx.doi.org/10.3390/ijerph16071258
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author Tuminello, Stephanie
van Gerwen, Maaike A. G.
Genden, Eric
Crane, Michael
Lieberman-Cribbin, Wil
Taioli, Emanuela
author_facet Tuminello, Stephanie
van Gerwen, Maaike A. G.
Genden, Eric
Crane, Michael
Lieberman-Cribbin, Wil
Taioli, Emanuela
author_sort Tuminello, Stephanie
collection PubMed
description An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (WTC) responders by looking at the demographic data and questionnaire responses of thyroid cancer cases from the Mount Sinai WTC Health Program (WTCHP). WTCHP thyroid cancer tumors were of a similar size (p = 0.4), and were diagnosed at a similar age (p = 0.2) compared to a subset of thyroid cancer cases treated at Mount Sinai without WTC exposure. These results do not support the surveillance bias hypothesis, under which smaller tumors are expected to be diagnosed at earlier ages. WTCHP thyroid cancer cases also reported a past history of radiation exposure and a family history of thyroid conditions at lower rates than expected, with higher than expected rates of previous cancer diagnoses, family histories of other cancers, and high Body Mass Indexes (BMIs). Further research is needed to better understand the underlying risk factors that may play a role in the development of thyroid cancer in this group.
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spelling pubmed-64796212019-04-29 Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment Tuminello, Stephanie van Gerwen, Maaike A. G. Genden, Eric Crane, Michael Lieberman-Cribbin, Wil Taioli, Emanuela Int J Environ Res Public Health Article An increased incidence of thyroid cancer among 9/11 rescue workers has been reported, the etiology of which remains unclear but which may, at least partly, be the result of the increased medical surveillance this group undergoes. This study aimed to investigate thyroid cancer in World Trade Center (WTC) responders by looking at the demographic data and questionnaire responses of thyroid cancer cases from the Mount Sinai WTC Health Program (WTCHP). WTCHP thyroid cancer tumors were of a similar size (p = 0.4), and were diagnosed at a similar age (p = 0.2) compared to a subset of thyroid cancer cases treated at Mount Sinai without WTC exposure. These results do not support the surveillance bias hypothesis, under which smaller tumors are expected to be diagnosed at earlier ages. WTCHP thyroid cancer cases also reported a past history of radiation exposure and a family history of thyroid conditions at lower rates than expected, with higher than expected rates of previous cancer diagnoses, family histories of other cancers, and high Body Mass Indexes (BMIs). Further research is needed to better understand the underlying risk factors that may play a role in the development of thyroid cancer in this group. MDPI 2019-04-09 2019-04 /pmc/articles/PMC6479621/ /pubmed/30970543 http://dx.doi.org/10.3390/ijerph16071258 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tuminello, Stephanie
van Gerwen, Maaike A. G.
Genden, Eric
Crane, Michael
Lieberman-Cribbin, Wil
Taioli, Emanuela
Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment
title Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment
title_full Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment
title_fullStr Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment
title_full_unstemmed Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment
title_short Increased Incidence of Thyroid Cancer among World Trade Center First Responders: A Descriptive Epidemiological Assessment
title_sort increased incidence of thyroid cancer among world trade center first responders: a descriptive epidemiological assessment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479621/
https://www.ncbi.nlm.nih.gov/pubmed/30970543
http://dx.doi.org/10.3390/ijerph16071258
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