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Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions

Adiponectin is the most abundant plasma adipokine. It mainly derives from white adipose tissue and plays a key role in the control of energy metabolism thanks to its insulin-sensitising, anti-inflammatory, and antiatherogenic properties. In vitro and in vivo evidence shows that adiponectin could als...

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Autores principales: Barbe, Alix, Bongrani, Alice, Mellouk, Namya, Estienne, Anthony, Kurowska, Patrycja, Grandhaye, Jérémy, Elfassy, Yaelle, Levy, Rachel, Rak, Agnieszka, Froment, Pascal, Dupont, Joëlle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479753/
https://www.ncbi.nlm.nih.gov/pubmed/30934676
http://dx.doi.org/10.3390/ijms20071526
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author Barbe, Alix
Bongrani, Alice
Mellouk, Namya
Estienne, Anthony
Kurowska, Patrycja
Grandhaye, Jérémy
Elfassy, Yaelle
Levy, Rachel
Rak, Agnieszka
Froment, Pascal
Dupont, Joëlle
author_facet Barbe, Alix
Bongrani, Alice
Mellouk, Namya
Estienne, Anthony
Kurowska, Patrycja
Grandhaye, Jérémy
Elfassy, Yaelle
Levy, Rachel
Rak, Agnieszka
Froment, Pascal
Dupont, Joëlle
author_sort Barbe, Alix
collection PubMed
description Adiponectin is the most abundant plasma adipokine. It mainly derives from white adipose tissue and plays a key role in the control of energy metabolism thanks to its insulin-sensitising, anti-inflammatory, and antiatherogenic properties. In vitro and in vivo evidence shows that adiponectin could also be one of the hormones controlling the interaction between energy balance and fertility in several species, including humans. Indeed, its two receptors—AdipoR1 and AdipoR2—are expressed in hypothalamic–pituitary–gonadal axis and their activation regulates Kiss, GnRH and gonadotropin expression and/or secretion. In male gonads, adiponectin modulates several functions of both somatic and germ cells, such as steroidogenesis, proliferation, apoptosis, and oxidative stress. In females, it controls steroidogenesis of ovarian granulosa and theca cells, oocyte maturation, and embryo development. Adiponectin receptors were also found in placental and endometrial cells, suggesting that this adipokine might play a crucial role in embryo implantation, trophoblast invasion and foetal growth. The aim of this review is to characterise adiponectin expression and its mechanism of action in male and female reproductive tract. Further, since features of metabolic syndrome are associated with some reproductive diseases, such as polycystic ovary syndrome, gestational diabetes mellitus, preeclampsia, endometriosis, foetal growth restriction and ovarian and endometrial cancers, evidence regarding the emerging role of adiponectin in these disorders is also discussed.
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spelling pubmed-64797532019-04-29 Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions Barbe, Alix Bongrani, Alice Mellouk, Namya Estienne, Anthony Kurowska, Patrycja Grandhaye, Jérémy Elfassy, Yaelle Levy, Rachel Rak, Agnieszka Froment, Pascal Dupont, Joëlle Int J Mol Sci Review Adiponectin is the most abundant plasma adipokine. It mainly derives from white adipose tissue and plays a key role in the control of energy metabolism thanks to its insulin-sensitising, anti-inflammatory, and antiatherogenic properties. In vitro and in vivo evidence shows that adiponectin could also be one of the hormones controlling the interaction between energy balance and fertility in several species, including humans. Indeed, its two receptors—AdipoR1 and AdipoR2—are expressed in hypothalamic–pituitary–gonadal axis and their activation regulates Kiss, GnRH and gonadotropin expression and/or secretion. In male gonads, adiponectin modulates several functions of both somatic and germ cells, such as steroidogenesis, proliferation, apoptosis, and oxidative stress. In females, it controls steroidogenesis of ovarian granulosa and theca cells, oocyte maturation, and embryo development. Adiponectin receptors were also found in placental and endometrial cells, suggesting that this adipokine might play a crucial role in embryo implantation, trophoblast invasion and foetal growth. The aim of this review is to characterise adiponectin expression and its mechanism of action in male and female reproductive tract. Further, since features of metabolic syndrome are associated with some reproductive diseases, such as polycystic ovary syndrome, gestational diabetes mellitus, preeclampsia, endometriosis, foetal growth restriction and ovarian and endometrial cancers, evidence regarding the emerging role of adiponectin in these disorders is also discussed. MDPI 2019-03-27 /pmc/articles/PMC6479753/ /pubmed/30934676 http://dx.doi.org/10.3390/ijms20071526 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Barbe, Alix
Bongrani, Alice
Mellouk, Namya
Estienne, Anthony
Kurowska, Patrycja
Grandhaye, Jérémy
Elfassy, Yaelle
Levy, Rachel
Rak, Agnieszka
Froment, Pascal
Dupont, Joëlle
Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions
title Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions
title_full Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions
title_fullStr Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions
title_full_unstemmed Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions
title_short Mechanisms of Adiponectin Action in Fertility: An Overview from Gametogenesis to Gestation in Humans and Animal Models in Normal and Pathological Conditions
title_sort mechanisms of adiponectin action in fertility: an overview from gametogenesis to gestation in humans and animal models in normal and pathological conditions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479753/
https://www.ncbi.nlm.nih.gov/pubmed/30934676
http://dx.doi.org/10.3390/ijms20071526
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