Cargando…
KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO–cGMP–MAPK Signaling Pathways
To test whether KMUP-1 (7-[2-[4-(2-chlorophenyl) piperazinyl]ethyl]-1,3-dimethylxanthine) prevents myocardial ischemia-induced apoptosis, we examined KMUP-1-treated H9c2 cells culture. Recent attention has focused on the activation of nitric oxide (NO)-guanosine 3’, 5’cyclic monophosphate (cGMP)-pro...
Autores principales: | Lee, Meng-Luen, Sulistyowati, Erna, Hsu, Jong-Hau, Huang, Bo-Yau, Dai, Zen-Kong, Wu, Bin-Nan, Chao, Yu-Ying, Yeh, Jwu-Lai |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479774/ https://www.ncbi.nlm.nih.gov/pubmed/30965668 http://dx.doi.org/10.3390/molecules24071376 |
Ejemplares similares
-
In Vitro Evaluation of the Anti-Inflammatory Effect of KMUP-1 and In Vivo Analysis of Its Therapeutic Potential in Osteoarthritis
por: Huang, Shang-En, et al.
Publicado: (2021) -
The Xanthine Derivative KMUP-1 Attenuates Serotonin-Induced Vasoconstriction and K(+)-Channel Inhibitory Activity via the PKC Pathway in Pulmonary Arteries
por: Dai, Zen-Kong, et al.
Publicado: (2015) -
Exogenous Heat Shock Cognate Protein 70 Suppresses LPS-Induced Inflammation by Down-Regulating NF-κB through MAPK and MMP-2/-9 Pathways in Macrophages
por: Sulistyowati, Erna, et al.
Publicado: (2018) -
KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways
por: Liou, Shu-Fen, et al.
Publicado: (2015) -
BK(Ca) Channel Inhibition by Peripheral Nerve Injury Is Restored by the Xanthine Derivative KMUP-1 in Dorsal Root Ganglia
por: Cheng, Kuang-I, et al.
Publicado: (2021)