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An IoT Based Architecture for Enhancing the Effectiveness of Prototype Medical Instruments Applied to Neurodegenerative Disease Diagnosis

Human errors are probably the most critical cause of the large amount of medical accidents. Medical cyber-physical systems (MCPS) have been suggested as a possible approach for detecting and limiting the impact of errors and wrong procedures. However, during the initial development phase of medical...

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Autores principales: Depari, Alessandro, Fernandes Carvalho, Dhiego, Bellagente, Paolo, Ferrari, Paolo, Sisinni, Emiliano, Flammini, Alessandra, Padovani, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479792/
https://www.ncbi.nlm.nih.gov/pubmed/30935157
http://dx.doi.org/10.3390/s19071564
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author Depari, Alessandro
Fernandes Carvalho, Dhiego
Bellagente, Paolo
Ferrari, Paolo
Sisinni, Emiliano
Flammini, Alessandra
Padovani, Alessandro
author_facet Depari, Alessandro
Fernandes Carvalho, Dhiego
Bellagente, Paolo
Ferrari, Paolo
Sisinni, Emiliano
Flammini, Alessandra
Padovani, Alessandro
author_sort Depari, Alessandro
collection PubMed
description Human errors are probably the most critical cause of the large amount of medical accidents. Medical cyber-physical systems (MCPS) have been suggested as a possible approach for detecting and limiting the impact of errors and wrong procedures. However, during the initial development phase of medical instruments, regular MCPS systems are not a viable approach, because of the high costs of repeating complex validation procedures, due to modifications of the prototype instrument. In this work, a communication architecture, inspired by recent Internet of Things (IoT) advances, is proposed for connecting prototype instruments to the cloud, to allow direct and real-time interaction between developers and instrument operators. Without loss of generality, a real-world use case is addressed, dealing with the use of transcranial magnetic stimulation (TMS) for neurodegenerative disease diagnosis. The proposed infrastructure leverages on a message-oriented middleware, complemented by historical database for further data processing. Two of the most diffused protocols for cloud data exchange (MQTT and AMQP) have been investigated. The experimental setup has been focused on the real-time performance, which are the most challenging requirements. Time-related metrics confirm the feasibility of the proposed approach, resulting in an end-to-end delay on the order of few tens of milliseconds for local networks and up to few hundreds of milliseconds for geographical scale networks.
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spelling pubmed-64797922019-04-29 An IoT Based Architecture for Enhancing the Effectiveness of Prototype Medical Instruments Applied to Neurodegenerative Disease Diagnosis Depari, Alessandro Fernandes Carvalho, Dhiego Bellagente, Paolo Ferrari, Paolo Sisinni, Emiliano Flammini, Alessandra Padovani, Alessandro Sensors (Basel) Article Human errors are probably the most critical cause of the large amount of medical accidents. Medical cyber-physical systems (MCPS) have been suggested as a possible approach for detecting and limiting the impact of errors and wrong procedures. However, during the initial development phase of medical instruments, regular MCPS systems are not a viable approach, because of the high costs of repeating complex validation procedures, due to modifications of the prototype instrument. In this work, a communication architecture, inspired by recent Internet of Things (IoT) advances, is proposed for connecting prototype instruments to the cloud, to allow direct and real-time interaction between developers and instrument operators. Without loss of generality, a real-world use case is addressed, dealing with the use of transcranial magnetic stimulation (TMS) for neurodegenerative disease diagnosis. The proposed infrastructure leverages on a message-oriented middleware, complemented by historical database for further data processing. Two of the most diffused protocols for cloud data exchange (MQTT and AMQP) have been investigated. The experimental setup has been focused on the real-time performance, which are the most challenging requirements. Time-related metrics confirm the feasibility of the proposed approach, resulting in an end-to-end delay on the order of few tens of milliseconds for local networks and up to few hundreds of milliseconds for geographical scale networks. MDPI 2019-03-31 /pmc/articles/PMC6479792/ /pubmed/30935157 http://dx.doi.org/10.3390/s19071564 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Depari, Alessandro
Fernandes Carvalho, Dhiego
Bellagente, Paolo
Ferrari, Paolo
Sisinni, Emiliano
Flammini, Alessandra
Padovani, Alessandro
An IoT Based Architecture for Enhancing the Effectiveness of Prototype Medical Instruments Applied to Neurodegenerative Disease Diagnosis
title An IoT Based Architecture for Enhancing the Effectiveness of Prototype Medical Instruments Applied to Neurodegenerative Disease Diagnosis
title_full An IoT Based Architecture for Enhancing the Effectiveness of Prototype Medical Instruments Applied to Neurodegenerative Disease Diagnosis
title_fullStr An IoT Based Architecture for Enhancing the Effectiveness of Prototype Medical Instruments Applied to Neurodegenerative Disease Diagnosis
title_full_unstemmed An IoT Based Architecture for Enhancing the Effectiveness of Prototype Medical Instruments Applied to Neurodegenerative Disease Diagnosis
title_short An IoT Based Architecture for Enhancing the Effectiveness of Prototype Medical Instruments Applied to Neurodegenerative Disease Diagnosis
title_sort iot based architecture for enhancing the effectiveness of prototype medical instruments applied to neurodegenerative disease diagnosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479792/
https://www.ncbi.nlm.nih.gov/pubmed/30935157
http://dx.doi.org/10.3390/s19071564
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