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Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities

Thymidylate synthase (TS) is an enzyme of paramount importance as it provides the only de novo source of deoxy-thymidine monophosphate (dTMP). dTMP, essential for DNA synthesis, is produced by the TS-catalyzed reductive methylation of 2′-deoxyuridine-5′-monophosphate (dUMP) using N(5),N(10)-methylen...

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Detalles Bibliográficos
Autores principales:	Pozzi, Cecilia, Ferrari, Stefania, Luciani, Rosaria, Tassone, Giusy, Costi, Maria Paola, Mangani, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479881/ https://www.ncbi.nlm.nih.gov/pubmed/30935102 http://dx.doi.org/10.3390/molecules24071257

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