Potential Pharmacokinetic Drug–Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive N-Methyl-d-Aspartate Receptor Antagonist

Harmine (HAR) is a beta-carboline alkaloid widely distributed in nature. It exhibits psychopharmacological effects of improving learning and memory. However, excessive dose of HAR can cause central tremor toxicity, which may be related to the glutamate system. Memantine (MEM) is a non-competitive N-...

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Detalles Bibliográficos
Autores principales: Zhang, Yunpeng, Li, Shuping, Wang, Youxu, Deng, Gang, Cao, Ning, Wu, Chao, Ding, Wenzheng, Wang, Yuwen, Cheng, Xuemei, Wang, Changhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479946/
https://www.ncbi.nlm.nih.gov/pubmed/30978991
http://dx.doi.org/10.3390/molecules24071430

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