Cargando…

Human Multilineage 3D Spheroids as a Model of Liver Steatosis and Fibrosis

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in western countries. Despite the high prevalence of NAFLD, the underlying biology of the disease progression is not clear, and there are no approved drugs to treat non-alcoholic steatohepatitis (NASH), the most advanced for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pingitore, Piero, Sasidharan, Kavitha, Ekstrand, Matias, Prill, Sebastian, Lindén, Daniel, Romeo, Stefano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480107/ https://www.ncbi.nlm.nih.gov/pubmed/30986904 http://dx.doi.org/10.3390/ijms20071629

Ejemplares similares

The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids
por: Prill, Sebastian, et al.
Publicado: (2019)

The Role of CTGF in Liver Fibrosis Induced in 3D Human Liver Spheroids
por: Trampuž, Sara Redenšek, et al.
Publicado: (2023)

Human hepatic 3D spheroids as a model for steatosis and insulin resistance
por: Kozyra, Mikael, et al.
Publicado: (2018)

Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis
por: Turola, Elena, et al.
Publicado: (2015)

PNPLA3 148M Carriers with Inflammatory Bowel Diseases Have Higher Susceptibility to Hepatic Steatosis and Higher Liver Enzymes
por: Mancina, Rosellina Margherita, et al.
Publicado: (2015)

Update of liver fibrosis and steatosis with transient elastography (Fibroscan)
por: Wong, Grace Lai-Hung
Publicado: (2013)

The effect of steatosis and fibrosis on blunt force vulnerability of the liver
por: Simon, Gábor, et al.
Publicado: (2020)

Hepatorenal index for grading liver steatosis with concomitant fibrosis
por: Stahlschmidt, Fabio Lucio, et al.
Publicado: (2021)

Association between hypertension and the prevalence of liver steatosis and fibrosis
por: Fu, Huanjie, et al.
Publicado: (2023)

Neuronal vulnerability and multilineage diversity in multiple sclerosis
por: Schirmer, Lucas, et al.
Publicado: (2019)

Mobilization of multilineage-differentiating stress-enduring cells into the peripheral blood in liver surgery
por: Kikuchi, Koji, et al.
Publicado: (2022)

Human Liver Spheroids as a Model to Study Aetiology and Treatment of Hepatic Fibrosis
por: Hurrell, Tracey, et al.
Publicado: (2020)

Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
por: Lindén, Daniel, et al.
Publicado: (2019)

Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver Organoids
por: Velazquez, Jeremy J., et al.
Publicado: (2020)

Is endocan a novel potential biomarker of liver steatosis and fibrosis?
por: Klisić, Aleksandra, et al.
Publicado: (2020)

Discovery and Targeting of the Signaling Controls of PNPLA3 to Effectively Reduce Transcription, Expression, and Function in Pre-Clinical NAFLD/NASH Settings
por: Schwartz, Brian E., et al.
Publicado: (2020)

Improved multilineage human hematopoietic reconstitution and function in NSGS mice
por: Wunderlich, Mark, et al.
Publicado: (2018)

The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis
por: Liu, Zhengtao, et al.
Publicado: (2017)

Weight Gain and Liver Steatosis in Patients with Inflammatory Bowel Diseases
por: Spagnuolo, Rocco, et al.
Publicado: (2019)

Gangliosides and Their Role in Multilineage Differentiation of Mesenchymal Stem Cells
por: Santilli, Francesca, et al.
Publicado: (2022)

Noninvasive markers of liver steatosis and fibrosis after liver transplantation – Where do we stand?
por: Mikolasevic, Ivana, et al.
Publicado: (2021)

Liver Fibrosis and Steatosis in Alström Syndrome: A Genetic Model for Metabolic Syndrome
por: Bettini, Silvia, et al.
Publicado: (2021)

A Comprehensive Review of Liver Allograft Fibrosis and Steatosis: From Cause to Diagnosis
por: Rabindranath, Madhumitha, et al.
Publicado: (2023)

Intestinal Pgc1α ablation protects from liver steatosis and fibrosis
por: Piccinin, Elena, et al.
Publicado: (2023)

Hepatic Fibrosis and Steatosis in Metabolic Syndrome
por: Gangireddy, Venu Gopala Reddy, et al.
Publicado: (2022)

Lipid rafts mediate multilineage differentiation of human dental pulp-derived stem cells (DPSCs)
por: Santilli, Francesca, et al.
Publicado: (2023)

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells
por: Meletis, Konstantinos, et al.
Publicado: (2008)

Mature T-lineage leukemia with growth factor-induced multilineage differentiation
Publicado: (1989)

Plasma proteome changes associated with refractory cytopenia with multilineage dysplasia
por: Májek, Pavel, et al.
Publicado: (2011)

Alteration in Endoglin-Related Angiogenesis in Refractory Cytopenia with Multilineage Dysplasia
por: del Rey, Mónica, et al.
Publicado: (2013)

Stable multilineage xenogeneic replacement of definitive hematopoiesis in adult zebrafish
por: Hess, Isabell, et al.
Publicado: (2016)

Biliary Obstruction Promotes Multilineage Differentiation of Hepatic Stem Cells
por: Yovchev, Mladen I., et al.
Publicado: (2019)

Myelodysplastic syndrome: validation of flow cytometry multilineage score system
por: de Araújo, Helena Varela, et al.
Publicado: (2020)

Erythrodermic Leukemia Cutis in Patient with Myelodysplastic Syndrome with Multilineage Dysplasia
por: Viviani, Filippo, et al.
Publicado: (2022)

Multilineage commitment of Sca-1(+) cells in reshaping vein grafts
por: Ni, Zhichao, et al.
Publicado: (2023)

Dedifferentiation of Human Primary Thyrocytes into Multilineage Progenitor Cells without Gene Introduction
por: Suzuki, Keiji, et al.
Publicado: (2011)

Multilineage differentiation of human bone marrow mesenchymal stem cells in vitro and in vivo
por: ZHENG, YOU-HUA, et al.
Publicado: (2013)

Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis
por: Di Ciaula, Agostino, et al.
Publicado: (2022)

Assessment of Steatosis and Fibrosis in Liver Transplant Recipients Using Controlled Attenuation Parameter and Liver Stiffness Measurements
por: Mikolasevic, Ivana, et al.
Publicado: (2021)

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation
por: Celiz, Adam D., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_0qe294vjc44l2amtkqmvbt5l9j