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Are There Thresholds in Glioblastoma Cell Death Responses Triggered by Temozolomide?
Temozolomide (TMZ) is an alkylating agent used in the treatment of high-grade malignant glioma, notably glioblastoma multiforme, the most aggressive form of brain cancer. The drug induces a dozen DNA methylation adducts, including O(6)-methylguanine (O(6)MeG), which is the most toxic primary DNA les...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480213/ https://www.ncbi.nlm.nih.gov/pubmed/30925722 http://dx.doi.org/10.3390/ijms20071562 |