The Emerging Role of Electrophiles as a Key Regulator for Endoplasmic Reticulum (ER) Stress

The unfolded protein response (UPR) is activated by the accumulation of misfolded proteins in the endoplasmic reticulum (ER), which is called ER stress. ER stress sensors PERK, IRE1, and ATF6 play a central role in the initiation and regulation of the UPR; they inhibit novel protein synthesis and up...

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Detalles Bibliográficos
Autores principales: Takasugi, Nobumasa, Hiraoka, Hideki, Nakahara, Kengo, Akiyama, Shiori, Fujikawa, Kana, Nomura, Ryosuke, Furuichi, Moeka, Uehara, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480251/
https://www.ncbi.nlm.nih.gov/pubmed/30974903
http://dx.doi.org/10.3390/ijms20071783

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