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Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis
Seven resorcylic acid lactones (RALs) including five new analog rhinoclactones, A–E (1, 2, 4–6), were isolated from an endophytic fungus Rhinocladiella similis in the plant Agriophyllum squarrosum collected from the Tengger Desert of the Ningxia Province, China. The structures of these new compounds...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480478/ https://www.ncbi.nlm.nih.gov/pubmed/30974765 http://dx.doi.org/10.3390/molecules24071405 |
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author | Li, Luying Zhang, Xiaoyan Tan, Xiangmei Sun, Bingda Wu, Bin Yu, Meng Zhang, Tao Zhang, Yonggang Ding, Gang |
author_facet | Li, Luying Zhang, Xiaoyan Tan, Xiangmei Sun, Bingda Wu, Bin Yu, Meng Zhang, Tao Zhang, Yonggang Ding, Gang |
author_sort | Li, Luying |
collection | PubMed |
description | Seven resorcylic acid lactones (RALs) including five new analog rhinoclactones, A–E (1, 2, 4–6), were isolated from an endophytic fungus Rhinocladiella similis in the plant Agriophyllum squarrosum collected from the Tengger Desert of the Ningxia Province, China. The structures of these new compounds were determined by HR-ESI-MS (High Resolution Electrospray Ionization Mass Spectrometry), NMR data, modified Mosher’s method, and X-ray diffraction experiments. All compounds isolated from this fungus possessed the 16-OMe/14-OH, not the common 16-OH/14-OH or 16-OH/14-OMe groups on the aromatic ring, which are rarely found in nature. Compound 7 displayed cytotoxic activities against HCT116 and HeLa cancer cell lines. The possible biosynthesis of 1–7 is suggested, and the potential ecological roles of these fungal secondary metabolites is discussed. |
format | Online Article Text |
id | pubmed-6480478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64804782019-04-30 Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis Li, Luying Zhang, Xiaoyan Tan, Xiangmei Sun, Bingda Wu, Bin Yu, Meng Zhang, Tao Zhang, Yonggang Ding, Gang Molecules Article Seven resorcylic acid lactones (RALs) including five new analog rhinoclactones, A–E (1, 2, 4–6), were isolated from an endophytic fungus Rhinocladiella similis in the plant Agriophyllum squarrosum collected from the Tengger Desert of the Ningxia Province, China. The structures of these new compounds were determined by HR-ESI-MS (High Resolution Electrospray Ionization Mass Spectrometry), NMR data, modified Mosher’s method, and X-ray diffraction experiments. All compounds isolated from this fungus possessed the 16-OMe/14-OH, not the common 16-OH/14-OH or 16-OH/14-OMe groups on the aromatic ring, which are rarely found in nature. Compound 7 displayed cytotoxic activities against HCT116 and HeLa cancer cell lines. The possible biosynthesis of 1–7 is suggested, and the potential ecological roles of these fungal secondary metabolites is discussed. MDPI 2019-04-10 /pmc/articles/PMC6480478/ /pubmed/30974765 http://dx.doi.org/10.3390/molecules24071405 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Luying Zhang, Xiaoyan Tan, Xiangmei Sun, Bingda Wu, Bin Yu, Meng Zhang, Tao Zhang, Yonggang Ding, Gang Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis |
title | Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis |
title_full | Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis |
title_fullStr | Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis |
title_full_unstemmed | Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis |
title_short | Rhinoclactones A-E, Resorcylic Acid Analogs from Desert Plant Endophytic Fungus Rhinocladiella similis |
title_sort | rhinoclactones a-e, resorcylic acid analogs from desert plant endophytic fungus rhinocladiella similis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480478/ https://www.ncbi.nlm.nih.gov/pubmed/30974765 http://dx.doi.org/10.3390/molecules24071405 |
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