The BET Bromodomain Inhibitor I-BET-151 Induces Structural and Functional Alterations of the Heart Mitochondria in Healthy Male Mice and Rats

The bromodomain and extra-terminal domain family inhibitors (BETi) are a promising new class of anticancer agents. Since numerous anticancer drugs have been correlated to cardiomyopathy, and since BETi can affect non-cancerous tissues, we aimed to investigate in healthy animals any ultrastructural B...

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Detalles Bibliográficos
Autores principales: Piquereau, Jérôme, Boet, Angèle, Péchoux, Christine, Antigny, Fabrice, Lambert, Mélanie, Gressette, Mélanie, Ranchoux, Benoît, Gambaryan, Natalia, Domergue, Valérie, Mumby, Sharon, Montani, David, Adcock, Ian M., Humbert, Marc, Garnier, Anne, Rucker-Martin, Catherine, Perros, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480532/
https://www.ncbi.nlm.nih.gov/pubmed/30934680
http://dx.doi.org/10.3390/ijms20071527

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