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A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor
In this study, biosensors based on zinc oxide–copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were compared. The uniform nano-crystalline sensor surface...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480568/ https://www.ncbi.nlm.nih.gov/pubmed/30959878 http://dx.doi.org/10.3390/ma12071126 |
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author | Cao, Lu Kiely, Janice Piano, Martina Luxton, Richard |
author_facet | Cao, Lu Kiely, Janice Piano, Martina Luxton, Richard |
author_sort | Cao, Lu |
collection | PubMed |
description | In this study, biosensors based on zinc oxide–copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were compared. The uniform nano-crystalline sensor surfaces on polyethylene terephthalate (PET) were analysed using scanning electron microscopy (SEM), Atomic Force Microscopy (AFM) and Raman Spectroscopy. The ZnO–CuO composite biosensor nano-surfaces showed a significantly increased impedimetric signal compared with pure ZnO nanocrystals, and the maximum output was achieved with a volume ratio of 1:2 ZnO/CuO. The antibody capture of C-reactive protein (CRP) on the nano-surfaces was used to demonstrate the enhanced signal generated with increasing amounts of CuO in the nano-surface. |
format | Online Article Text |
id | pubmed-6480568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64805682019-04-29 A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor Cao, Lu Kiely, Janice Piano, Martina Luxton, Richard Materials (Basel) Article In this study, biosensors based on zinc oxide–copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were compared. The uniform nano-crystalline sensor surfaces on polyethylene terephthalate (PET) were analysed using scanning electron microscopy (SEM), Atomic Force Microscopy (AFM) and Raman Spectroscopy. The ZnO–CuO composite biosensor nano-surfaces showed a significantly increased impedimetric signal compared with pure ZnO nanocrystals, and the maximum output was achieved with a volume ratio of 1:2 ZnO/CuO. The antibody capture of C-reactive protein (CRP) on the nano-surfaces was used to demonstrate the enhanced signal generated with increasing amounts of CuO in the nano-surface. MDPI 2019-04-06 /pmc/articles/PMC6480568/ /pubmed/30959878 http://dx.doi.org/10.3390/ma12071126 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cao, Lu Kiely, Janice Piano, Martina Luxton, Richard A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor |
title | A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor |
title_full | A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor |
title_fullStr | A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor |
title_full_unstemmed | A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor |
title_short | A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor |
title_sort | copper oxide/zinc oxide composite nano-surface for use in a biosensor |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480568/ https://www.ncbi.nlm.nih.gov/pubmed/30959878 http://dx.doi.org/10.3390/ma12071126 |
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