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A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor

In this study, biosensors based on zinc oxide–copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were compared. The uniform nano-crystalline sensor surface...

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Detalles Bibliográficos
Autores principales: Cao, Lu, Kiely, Janice, Piano, Martina, Luxton, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480568/
https://www.ncbi.nlm.nih.gov/pubmed/30959878
http://dx.doi.org/10.3390/ma12071126
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author Cao, Lu
Kiely, Janice
Piano, Martina
Luxton, Richard
author_facet Cao, Lu
Kiely, Janice
Piano, Martina
Luxton, Richard
author_sort Cao, Lu
collection PubMed
description In this study, biosensors based on zinc oxide–copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were compared. The uniform nano-crystalline sensor surfaces on polyethylene terephthalate (PET) were analysed using scanning electron microscopy (SEM), Atomic Force Microscopy (AFM) and Raman Spectroscopy. The ZnO–CuO composite biosensor nano-surfaces showed a significantly increased impedimetric signal compared with pure ZnO nanocrystals, and the maximum output was achieved with a volume ratio of 1:2 ZnO/CuO. The antibody capture of C-reactive protein (CRP) on the nano-surfaces was used to demonstrate the enhanced signal generated with increasing amounts of CuO in the nano-surface.
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spelling pubmed-64805682019-04-29 A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor Cao, Lu Kiely, Janice Piano, Martina Luxton, Richard Materials (Basel) Article In this study, biosensors based on zinc oxide–copper oxide composite nano-surfaces were prepared using a simple and inexpensive distributed colloidal technique. Combinations of mixed dispersions with volume ratios of 1:1, 1:2 and 2:1 ZnO:CuO were compared. The uniform nano-crystalline sensor surfaces on polyethylene terephthalate (PET) were analysed using scanning electron microscopy (SEM), Atomic Force Microscopy (AFM) and Raman Spectroscopy. The ZnO–CuO composite biosensor nano-surfaces showed a significantly increased impedimetric signal compared with pure ZnO nanocrystals, and the maximum output was achieved with a volume ratio of 1:2 ZnO/CuO. The antibody capture of C-reactive protein (CRP) on the nano-surfaces was used to demonstrate the enhanced signal generated with increasing amounts of CuO in the nano-surface. MDPI 2019-04-06 /pmc/articles/PMC6480568/ /pubmed/30959878 http://dx.doi.org/10.3390/ma12071126 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cao, Lu
Kiely, Janice
Piano, Martina
Luxton, Richard
A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor
title A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor
title_full A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor
title_fullStr A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor
title_full_unstemmed A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor
title_short A Copper Oxide/Zinc Oxide Composite Nano-Surface for Use in a Biosensor
title_sort copper oxide/zinc oxide composite nano-surface for use in a biosensor
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480568/
https://www.ncbi.nlm.nih.gov/pubmed/30959878
http://dx.doi.org/10.3390/ma12071126
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