Cargando…
Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial
OBJECTIVES: To determine the efficacy of platelet-rich plasma (PRP) compared to lidocaine as a tenotomy adjuvant for people with elbow tendinopathy. METHODS: Our study was a parallel-group, double-blind, randomized trial involving 71 patients with recalcitrant elbow tendinopathy who received two ses...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480601/ https://www.ncbi.nlm.nih.gov/pubmed/31014382 http://dx.doi.org/10.1186/s13018-019-1153-6 |
_version_ | 1783413602898673664 |
---|---|
author | Martin, Jose Ignacio Atilano, Leire Merino, Josu Gonzalez, Igor Iglesias, Gotzon Areizaga, Luis Bully, Paola Grandes, Gonzalo Andia, Isabel |
author_facet | Martin, Jose Ignacio Atilano, Leire Merino, Josu Gonzalez, Igor Iglesias, Gotzon Areizaga, Luis Bully, Paola Grandes, Gonzalo Andia, Isabel |
author_sort | Martin, Jose Ignacio |
collection | PubMed |
description | OBJECTIVES: To determine the efficacy of platelet-rich plasma (PRP) compared to lidocaine as a tenotomy adjuvant for people with elbow tendinopathy. METHODS: Our study was a parallel-group, double-blind, randomized trial involving 71 patients with recalcitrant elbow tendinopathy who received two sessions of ultrasound-guided tenotomy with either PRP or lidocaine in a tertiary public hospital. The primary end point was the percentage of patients with an improvement exceeding 25% reduction in disability (Spanish version of the Disabilities of the Arm, Shoulder and Hand questionnaires–DASH-E) at 6 and 12 months; the secondary outcome was the percentage of patients exceeding 25% reduction in pain (VAS-P). RESULTS: There was no evidence of significant differences in the proportion of patients who experienced clinically relevant improvements. After 6 months, 18 patients (78.59%) in the lidocaine group and 19 patients (73.08%) in the PRP group showed improved function above 25% (unadjusted odds ratio, 0.90; 95% confidence interval [CI], 0.90 (0.17 to 4.60)); 21 patients (72.21%) in the lidocaine group versus 22 patients (84.62%) in the PRP group achieved more than 25% pain reduction (unadjusted odds ratio, 0.48; 95% CI, 0.10 to 2.37). After 12 months, 17 patients (70.83%) in the lidocaine group versus 19 patients (76%) in the PRP group had improved function (unadjusted odds ratio, 0.71; 95% CI, 0.13 to 3.84), and 19 patients (76%) in the lidocaine group versus 20 patients (90.91%) in the PRP group had improved pain above 25% (unadjusted odds ratio, 0.35; 95% CI, 0.06 to 2.51). Hypercholesterolemia and baseline vascularization influenced outcomes. There were no differences between groups in the adjusted odds ratios. CONCLUSION: PRP results in similar improvements to those obtained with lidocaine. Selecting patients according to their pretreatment status can improve treatment efficacy. TRIAL REGISTRATION: NCT01945528, EudraCT 2013-000478-32. Registered 18 August 2013, enrolment of the first participant 10 March 2014 |
format | Online Article Text |
id | pubmed-6480601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-64806012019-05-01 Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial Martin, Jose Ignacio Atilano, Leire Merino, Josu Gonzalez, Igor Iglesias, Gotzon Areizaga, Luis Bully, Paola Grandes, Gonzalo Andia, Isabel J Orthop Surg Res Research Article OBJECTIVES: To determine the efficacy of platelet-rich plasma (PRP) compared to lidocaine as a tenotomy adjuvant for people with elbow tendinopathy. METHODS: Our study was a parallel-group, double-blind, randomized trial involving 71 patients with recalcitrant elbow tendinopathy who received two sessions of ultrasound-guided tenotomy with either PRP or lidocaine in a tertiary public hospital. The primary end point was the percentage of patients with an improvement exceeding 25% reduction in disability (Spanish version of the Disabilities of the Arm, Shoulder and Hand questionnaires–DASH-E) at 6 and 12 months; the secondary outcome was the percentage of patients exceeding 25% reduction in pain (VAS-P). RESULTS: There was no evidence of significant differences in the proportion of patients who experienced clinically relevant improvements. After 6 months, 18 patients (78.59%) in the lidocaine group and 19 patients (73.08%) in the PRP group showed improved function above 25% (unadjusted odds ratio, 0.90; 95% confidence interval [CI], 0.90 (0.17 to 4.60)); 21 patients (72.21%) in the lidocaine group versus 22 patients (84.62%) in the PRP group achieved more than 25% pain reduction (unadjusted odds ratio, 0.48; 95% CI, 0.10 to 2.37). After 12 months, 17 patients (70.83%) in the lidocaine group versus 19 patients (76%) in the PRP group had improved function (unadjusted odds ratio, 0.71; 95% CI, 0.13 to 3.84), and 19 patients (76%) in the lidocaine group versus 20 patients (90.91%) in the PRP group had improved pain above 25% (unadjusted odds ratio, 0.35; 95% CI, 0.06 to 2.51). Hypercholesterolemia and baseline vascularization influenced outcomes. There were no differences between groups in the adjusted odds ratios. CONCLUSION: PRP results in similar improvements to those obtained with lidocaine. Selecting patients according to their pretreatment status can improve treatment efficacy. TRIAL REGISTRATION: NCT01945528, EudraCT 2013-000478-32. Registered 18 August 2013, enrolment of the first participant 10 March 2014 BioMed Central 2019-04-23 /pmc/articles/PMC6480601/ /pubmed/31014382 http://dx.doi.org/10.1186/s13018-019-1153-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Martin, Jose Ignacio Atilano, Leire Merino, Josu Gonzalez, Igor Iglesias, Gotzon Areizaga, Luis Bully, Paola Grandes, Gonzalo Andia, Isabel Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial |
title | Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial |
title_full | Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial |
title_fullStr | Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial |
title_full_unstemmed | Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial |
title_short | Platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial |
title_sort | platelet-rich plasma versus lidocaine as tenotomy adjuvants in people with elbow epicondylopathy: a randomized controlled trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480601/ https://www.ncbi.nlm.nih.gov/pubmed/31014382 http://dx.doi.org/10.1186/s13018-019-1153-6 |
work_keys_str_mv | AT martinjoseignacio plateletrichplasmaversuslidocaineastenotomyadjuvantsinpeoplewithelbowepicondylopathyarandomizedcontrolledtrial AT atilanoleire plateletrichplasmaversuslidocaineastenotomyadjuvantsinpeoplewithelbowepicondylopathyarandomizedcontrolledtrial AT merinojosu plateletrichplasmaversuslidocaineastenotomyadjuvantsinpeoplewithelbowepicondylopathyarandomizedcontrolledtrial AT gonzalezigor plateletrichplasmaversuslidocaineastenotomyadjuvantsinpeoplewithelbowepicondylopathyarandomizedcontrolledtrial AT iglesiasgotzon plateletrichplasmaversuslidocaineastenotomyadjuvantsinpeoplewithelbowepicondylopathyarandomizedcontrolledtrial AT areizagaluis plateletrichplasmaversuslidocaineastenotomyadjuvantsinpeoplewithelbowepicondylopathyarandomizedcontrolledtrial AT bullypaola plateletrichplasmaversuslidocaineastenotomyadjuvantsinpeoplewithelbowepicondylopathyarandomizedcontrolledtrial AT grandesgonzalo plateletrichplasmaversuslidocaineastenotomyadjuvantsinpeoplewithelbowepicondylopathyarandomizedcontrolledtrial AT andiaisabel plateletrichplasmaversuslidocaineastenotomyadjuvantsinpeoplewithelbowepicondylopathyarandomizedcontrolledtrial |