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Treatment verification using Varian’s dynalog files in the Monte Carlo system PRIMO

BACKGROUND: The PRIMO system is a computer software that allows the Monte Carlo simulation of linear accelerators and the estimation of the subsequent absorbed dose distributions in phantoms and computed tomographies. The aim of this work is to validate the methods incorporated in PRIMO to evaluate...

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Autores principales: Rodriguez, Miguel, Brualla, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480709/
https://www.ncbi.nlm.nih.gov/pubmed/31014356
http://dx.doi.org/10.1186/s13014-019-1269-1
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author Rodriguez, Miguel
Brualla, Lorenzo
author_facet Rodriguez, Miguel
Brualla, Lorenzo
author_sort Rodriguez, Miguel
collection PubMed
description BACKGROUND: The PRIMO system is a computer software that allows the Monte Carlo simulation of linear accelerators and the estimation of the subsequent absorbed dose distributions in phantoms and computed tomographies. The aim of this work is to validate the methods incorporated in PRIMO to evaluate the deviations introduced in the dose distributions by errors in the positioning of the leaves of the multileaf collimator recorded in the dynalog files during patient treatment. METHODS: The reconstruction of treatment plans from Varian’s dynalog files was implemented in the PRIMO system. Dose distributions were estimated for volumetric-modulated arc therapy clinical cases of prostate and head&neck using the PRIMO fast Monte Carlo engine DPM. Accuracy of the implemented reconstruction methods was evaluated by comparing dose distributions obtained from the simulations of the plans imported from the treatment planning system with those obtained from the simulations of the plans reconstructed from the expected leaves positions recorded in the dynalog files. The impact on the dose of errors in the positions of the leaves was evaluated by comparing dose distributions estimated for plans reconstructed from expected leaves positions with dose distributions estimated from actual leaves positions. Gamma pass rate (GPR), a hereby introduced quantity named percentage of agreement (PA) and the percentage of voxels with a given systematic difference (α/Δ) were the quantities used for the comparisons. Errors were introduced in leaves positions in order to study the sensitivity of these quantities. RESULTS: A good agreement of the dose distributions obtained from the plan imported from the TPS and from the plan reconstructed from expected leaves positions was obtained. Not a significantly better agreement was obtained for an imported plan with an increased number of control points such as to approximately match the number of records in the dynalogs. When introduced errors were predominantly in one direction, the methods employed in this work were sensitive to dynalogs with root-mean-square errors (RMS) ≥0.2 mm. Nevertheless, when errors were in both directions, only RMS >1.2 mm produced detectable deviations in the dose. The PA and the α/Δ showed more sensitive to errors in the leaves positions than the GPR. CONCLUSIONS: Methods to verify the accuracy of the radiotherapy treatment from the information recorded in the Varian’s dynalog files were implemented and verified in this work for the PRIMO system. Tolerance limits could be established based on the values of PA and α/Δ. GPR (3,3) is not recommended as a solely evaluator of deviations introduced in the dose by errors captured in the dynalog files.
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spelling pubmed-64807092019-05-01 Treatment verification using Varian’s dynalog files in the Monte Carlo system PRIMO Rodriguez, Miguel Brualla, Lorenzo Radiat Oncol Research BACKGROUND: The PRIMO system is a computer software that allows the Monte Carlo simulation of linear accelerators and the estimation of the subsequent absorbed dose distributions in phantoms and computed tomographies. The aim of this work is to validate the methods incorporated in PRIMO to evaluate the deviations introduced in the dose distributions by errors in the positioning of the leaves of the multileaf collimator recorded in the dynalog files during patient treatment. METHODS: The reconstruction of treatment plans from Varian’s dynalog files was implemented in the PRIMO system. Dose distributions were estimated for volumetric-modulated arc therapy clinical cases of prostate and head&neck using the PRIMO fast Monte Carlo engine DPM. Accuracy of the implemented reconstruction methods was evaluated by comparing dose distributions obtained from the simulations of the plans imported from the treatment planning system with those obtained from the simulations of the plans reconstructed from the expected leaves positions recorded in the dynalog files. The impact on the dose of errors in the positions of the leaves was evaluated by comparing dose distributions estimated for plans reconstructed from expected leaves positions with dose distributions estimated from actual leaves positions. Gamma pass rate (GPR), a hereby introduced quantity named percentage of agreement (PA) and the percentage of voxels with a given systematic difference (α/Δ) were the quantities used for the comparisons. Errors were introduced in leaves positions in order to study the sensitivity of these quantities. RESULTS: A good agreement of the dose distributions obtained from the plan imported from the TPS and from the plan reconstructed from expected leaves positions was obtained. Not a significantly better agreement was obtained for an imported plan with an increased number of control points such as to approximately match the number of records in the dynalogs. When introduced errors were predominantly in one direction, the methods employed in this work were sensitive to dynalogs with root-mean-square errors (RMS) ≥0.2 mm. Nevertheless, when errors were in both directions, only RMS >1.2 mm produced detectable deviations in the dose. The PA and the α/Δ showed more sensitive to errors in the leaves positions than the GPR. CONCLUSIONS: Methods to verify the accuracy of the radiotherapy treatment from the information recorded in the Varian’s dynalog files were implemented and verified in this work for the PRIMO system. Tolerance limits could be established based on the values of PA and α/Δ. GPR (3,3) is not recommended as a solely evaluator of deviations introduced in the dose by errors captured in the dynalog files. BioMed Central 2019-04-23 /pmc/articles/PMC6480709/ /pubmed/31014356 http://dx.doi.org/10.1186/s13014-019-1269-1 Text en © The Author(s) 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Rodriguez, Miguel
Brualla, Lorenzo
Treatment verification using Varian’s dynalog files in the Monte Carlo system PRIMO
title Treatment verification using Varian’s dynalog files in the Monte Carlo system PRIMO
title_full Treatment verification using Varian’s dynalog files in the Monte Carlo system PRIMO
title_fullStr Treatment verification using Varian’s dynalog files in the Monte Carlo system PRIMO
title_full_unstemmed Treatment verification using Varian’s dynalog files in the Monte Carlo system PRIMO
title_short Treatment verification using Varian’s dynalog files in the Monte Carlo system PRIMO
title_sort treatment verification using varian’s dynalog files in the monte carlo system primo
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480709/
https://www.ncbi.nlm.nih.gov/pubmed/31014356
http://dx.doi.org/10.1186/s13014-019-1269-1
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