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High prevalence of Pfmdr-1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda

OBJECTIVE: To determine the prevalence of Plasmodium falciparum multi-drug resistant gene-1 (Pfmdr-1) N86Y and D1246Y genotypes among febrile malaria outpatients attending Lira Regional Referral Hospital, Uganda. RESULTS: Overall, 92.3% (n = 48/52) and 90% (n = 45/50) of the parasites detected carri...

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Autores principales: Achol, Emmanuel, Ochaya, Stephen, Malinga, Geoffrey M., Edema, Hillary, Echodu, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480777/
https://www.ncbi.nlm.nih.gov/pubmed/31014391
http://dx.doi.org/10.1186/s13104-019-4269-1
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author Achol, Emmanuel
Ochaya, Stephen
Malinga, Geoffrey M.
Edema, Hillary
Echodu, Richard
author_facet Achol, Emmanuel
Ochaya, Stephen
Malinga, Geoffrey M.
Edema, Hillary
Echodu, Richard
author_sort Achol, Emmanuel
collection PubMed
description OBJECTIVE: To determine the prevalence of Plasmodium falciparum multi-drug resistant gene-1 (Pfmdr-1) N86Y and D1246Y genotypes among febrile malaria outpatients attending Lira Regional Referral Hospital, Uganda. RESULTS: Overall, 92.3% (n = 48/52) and 90% (n = 45/50) of the parasites detected carried the wild type alleles 1246D and N86, respectively. Only 7.7% (n = 4/52) and 10% (n = 5/50) of these P. falciparum isolates carried the Pfmdr-1 mutant alleles 1246Y and 86Y, respectively. Our results show high prevalence of wild type alleles N86 and D1246 in P. falciparum isolates from Lira Regional Referral Hospital, which could translate to a decreased sensitivity to artemether-lumefantrine. Continued monitoring of prevalence of single nucleotide polymorphisms is warranted to timely inform malaria treatment policies and guidelines.
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spelling pubmed-64807772019-05-01 High prevalence of Pfmdr-1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda Achol, Emmanuel Ochaya, Stephen Malinga, Geoffrey M. Edema, Hillary Echodu, Richard BMC Res Notes Research Note OBJECTIVE: To determine the prevalence of Plasmodium falciparum multi-drug resistant gene-1 (Pfmdr-1) N86Y and D1246Y genotypes among febrile malaria outpatients attending Lira Regional Referral Hospital, Uganda. RESULTS: Overall, 92.3% (n = 48/52) and 90% (n = 45/50) of the parasites detected carried the wild type alleles 1246D and N86, respectively. Only 7.7% (n = 4/52) and 10% (n = 5/50) of these P. falciparum isolates carried the Pfmdr-1 mutant alleles 1246Y and 86Y, respectively. Our results show high prevalence of wild type alleles N86 and D1246 in P. falciparum isolates from Lira Regional Referral Hospital, which could translate to a decreased sensitivity to artemether-lumefantrine. Continued monitoring of prevalence of single nucleotide polymorphisms is warranted to timely inform malaria treatment policies and guidelines. BioMed Central 2019-04-23 /pmc/articles/PMC6480777/ /pubmed/31014391 http://dx.doi.org/10.1186/s13104-019-4269-1 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Achol, Emmanuel
Ochaya, Stephen
Malinga, Geoffrey M.
Edema, Hillary
Echodu, Richard
High prevalence of Pfmdr-1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda
title High prevalence of Pfmdr-1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda
title_full High prevalence of Pfmdr-1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda
title_fullStr High prevalence of Pfmdr-1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda
title_full_unstemmed High prevalence of Pfmdr-1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda
title_short High prevalence of Pfmdr-1 N86 and D1246 genotypes detected among febrile malaria outpatients attending Lira Regional Referral Hospital, Northern Uganda
title_sort high prevalence of pfmdr-1 n86 and d1246 genotypes detected among febrile malaria outpatients attending lira regional referral hospital, northern uganda
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480777/
https://www.ncbi.nlm.nih.gov/pubmed/31014391
http://dx.doi.org/10.1186/s13104-019-4269-1
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