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Incorporating individual historical controls and aggregate treatment effect estimates into a Bayesian survival trial: a simulation study

BACKGROUND: Performing well-powered randomised controlled trials (RCTs) of new treatments for rare diseases is often infeasible. However, with the increasing availability of historical data, incorporating existing information into trials with small sample sizes is appealing in order to increase the...

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Detalles Bibliográficos
Autores principales:	Brard, Caroline, Hampson, Lisa V., Gaspar, Nathalie, Le Deley, Marie-Cécile, Le Teuff, Gwénaël
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480797/ https://www.ncbi.nlm.nih.gov/pubmed/31018832 http://dx.doi.org/10.1186/s12874-019-0714-z

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