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Sustained Glycemic Control With Ivacaftor in Cystic Fibrosis–Related Diabetes

Cystic fibrosis–related diabetes (CFRD) is a common comorbidity in cystic fibrosis with pancreatic insufficiency occurring early in the disease process. Current treatment is exogenous insulin therapy as CFRD is due to impaired insulin secretion. Recent small studies have shown improvement in endogen...

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Autores principales: Christian, Francis, Thierman, Andrew, Shirley, Erin, Allen, Karen, Cross, Cory, Jones, Kellie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480995/
https://www.ncbi.nlm.nih.gov/pubmed/31010313
http://dx.doi.org/10.1177/2324709619842898
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author Christian, Francis
Thierman, Andrew
Shirley, Erin
Allen, Karen
Cross, Cory
Jones, Kellie
author_facet Christian, Francis
Thierman, Andrew
Shirley, Erin
Allen, Karen
Cross, Cory
Jones, Kellie
author_sort Christian, Francis
collection PubMed
description Cystic fibrosis–related diabetes (CFRD) is a common comorbidity in cystic fibrosis with pancreatic insufficiency occurring early in the disease process. Current treatment is exogenous insulin therapy as CFRD is due to impaired insulin secretion. Recent small studies have shown improvement in endogenous insulin secretion with a short period of ivacaftor therapy in primarily pediatric patients with cystic fibrosis transmembrane conductance regulator mutations amenable to potentiation. In this article, we present the case of an adult patient with long-standing CFRD who developed sustained improvement in glycemic control after initiation of ivacaftor.
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spelling pubmed-64809952019-04-30 Sustained Glycemic Control With Ivacaftor in Cystic Fibrosis–Related Diabetes Christian, Francis Thierman, Andrew Shirley, Erin Allen, Karen Cross, Cory Jones, Kellie J Investig Med High Impact Case Rep Case Report Cystic fibrosis–related diabetes (CFRD) is a common comorbidity in cystic fibrosis with pancreatic insufficiency occurring early in the disease process. Current treatment is exogenous insulin therapy as CFRD is due to impaired insulin secretion. Recent small studies have shown improvement in endogenous insulin secretion with a short period of ivacaftor therapy in primarily pediatric patients with cystic fibrosis transmembrane conductance regulator mutations amenable to potentiation. In this article, we present the case of an adult patient with long-standing CFRD who developed sustained improvement in glycemic control after initiation of ivacaftor. SAGE Publications 2019-04-22 /pmc/articles/PMC6480995/ /pubmed/31010313 http://dx.doi.org/10.1177/2324709619842898 Text en © 2019 American Federation for Medical Research http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (http://www.creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Christian, Francis
Thierman, Andrew
Shirley, Erin
Allen, Karen
Cross, Cory
Jones, Kellie
Sustained Glycemic Control With Ivacaftor in Cystic Fibrosis–Related Diabetes
title Sustained Glycemic Control With Ivacaftor in Cystic Fibrosis–Related Diabetes
title_full Sustained Glycemic Control With Ivacaftor in Cystic Fibrosis–Related Diabetes
title_fullStr Sustained Glycemic Control With Ivacaftor in Cystic Fibrosis–Related Diabetes
title_full_unstemmed Sustained Glycemic Control With Ivacaftor in Cystic Fibrosis–Related Diabetes
title_short Sustained Glycemic Control With Ivacaftor in Cystic Fibrosis–Related Diabetes
title_sort sustained glycemic control with ivacaftor in cystic fibrosis–related diabetes
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6480995/
https://www.ncbi.nlm.nih.gov/pubmed/31010313
http://dx.doi.org/10.1177/2324709619842898
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