Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma

Acute disseminated intravascular coagulation (DIC) is a pathological process involving dysfunction of the coagulation cascade. In this case report, we discuss a 33-year-old woman with BRAF V600E-mutated metastatic melanoma who presented in fulminant DIC with concurrent hemorrhagic and thrombotic man...

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Detalles Bibliográficos
Autores principales: Chuang, Jeremy, Uche, An, Gupta, Rohan, Margolin, Kim, Kim, Phyllis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481122/
https://www.ncbi.nlm.nih.gov/pubmed/31093395
http://dx.doi.org/10.1155/2019/9246596
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author Chuang, Jeremy
Uche, An
Gupta, Rohan
Margolin, Kim
Kim, Phyllis
author_facet Chuang, Jeremy
Uche, An
Gupta, Rohan
Margolin, Kim
Kim, Phyllis
author_sort Chuang, Jeremy
collection PubMed
description Acute disseminated intravascular coagulation (DIC) is a pathological process involving dysfunction of the coagulation cascade. In this case report, we discuss a 33-year-old woman with BRAF V600E-mutated metastatic melanoma who presented in fulminant DIC with concurrent hemorrhagic and thrombotic manifestations and discuss the patient's brief response to combination therapy. In our discussion, we highlight the current understanding of DIC and also identify opportunities for future research to elucidate the genetic aberrations in melanoma that may result in treatment resistance to combination therapy.
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spelling pubmed-64811222019-05-15 Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma Chuang, Jeremy Uche, An Gupta, Rohan Margolin, Kim Kim, Phyllis Case Rep Oncol Med Case Report Acute disseminated intravascular coagulation (DIC) is a pathological process involving dysfunction of the coagulation cascade. In this case report, we discuss a 33-year-old woman with BRAF V600E-mutated metastatic melanoma who presented in fulminant DIC with concurrent hemorrhagic and thrombotic manifestations and discuss the patient's brief response to combination therapy. In our discussion, we highlight the current understanding of DIC and also identify opportunities for future research to elucidate the genetic aberrations in melanoma that may result in treatment resistance to combination therapy. Hindawi 2019-04-09 /pmc/articles/PMC6481122/ /pubmed/31093395 http://dx.doi.org/10.1155/2019/9246596 Text en Copyright © 2019 Jeremy Chuang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Chuang, Jeremy
Uche, An
Gupta, Rohan
Margolin, Kim
Kim, Phyllis
Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma
title Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma
title_full Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma
title_fullStr Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma
title_full_unstemmed Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma
title_short Fulminant Disseminated Intravascular Coagulation as Initial Presentation of BRAF-Mutated Melanoma
title_sort fulminant disseminated intravascular coagulation as initial presentation of braf-mutated melanoma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481122/
https://www.ncbi.nlm.nih.gov/pubmed/31093395
http://dx.doi.org/10.1155/2019/9246596
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