Breaking the cycle: Reversal of flux in the tricarboxylic acid cycle by dimethyl fumarate

OBJECTIVE: To infer molecular effectors of therapeutic effects and adverse events for dimethyl fumarate (DMF) in patients with relapsing-remitting MS (RRMS) using untargeted plasma metabolomics. METHODS: Plasma from 27 patients with RRMS was collected at baseline and 6 weeks after initiating DMF. Pa...

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Detalles Bibliográficos
Autores principales: Gafson, Arie R., Savva, Constantinos, Thorne, Tom, David, Mark, Gomez-Romero, Maria, Lewis, Matthew R., Nicholas, Richard, Heslegrave, Amanda, Zetterberg, Henrik, Matthews, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481230/
https://www.ncbi.nlm.nih.gov/pubmed/31086805
http://dx.doi.org/10.1212/NXI.0000000000000562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481230/
https://www.ncbi.nlm.nih.gov/pubmed/31086805
http://dx.doi.org/10.1212/NXI.0000000000000562

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