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Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process

CONTEXT: Weaning induced cardiac dysfunction can occur without underlying heart disease. Changes in intrathoracic pressure, systemic vascular resistance, preload and afterload leading to heart-lung interactions are the possible explanatory mechanisms AIMS: The aim of the current study was whether th...

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Autores principales: Amarja, Havaldar, Bhuvana, Krishna, Sriram, Sampath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481267/
https://www.ncbi.nlm.nih.gov/pubmed/31065203
http://dx.doi.org/10.5005/jp-journals-10071-23106
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author Amarja, Havaldar
Bhuvana, Krishna
Sriram, Sampath
author_facet Amarja, Havaldar
Bhuvana, Krishna
Sriram, Sampath
author_sort Amarja, Havaldar
collection PubMed
description CONTEXT: Weaning induced cardiac dysfunction can occur without underlying heart disease. Changes in intrathoracic pressure, systemic vascular resistance, preload and afterload leading to heart-lung interactions are the possible explanatory mechanisms AIMS: The aim of the current study was whether the assessment and identification of cardiac dysfunction induced during the weaning process could predict the outcome of extubation. SETTINGS AND DESIGN: A prospective observational study with convenience sampling method was conducted from May 2015 to April 2016 after institutional ethical committee approval (ref 161/2015). MATERIALS AND METHODS: Patients over eighteen and planned for extubation were included. Weaning method used was a spontaneous breathing trial (SBT) by pressure support-positive end-expiratory pressure (PS-PEEP). Baseline characteristics, weaning, and echocardiography parameters were collected pre extubation. Post-extubation echocardiographic parameters were collected within six hours as per the protocol. The primary outcome was extubation failure (reintubation within 48 hours). Secondary outcomes were ICU length of stay and ICU mortality. STATISTICAL ANALYSIS: Statistical method used is STATA™ (Version14, College Station TX). RESULTS: Out of one hundred and sixty-one patients, twenty-one failed extubation (13.04 %). Pre-extubation echocardiographic parameters were similar in two groups except for preexisting LV systolic dysfunction. Post-extubation E/e` (9.30 vs. 7.71 p = 0.018) was higher in the extubation failure group. Extubation failure group had higher intensive care unit (ICU) length of stay and ICU mortality. CONCLUSION: In our study E/e` during a weaning trial did not predict extubation success. Cardiac dysfunction induced during weaning may get masked during weaning and manifests postextubation. This needs to be verified in subsequent studies. KEY MESSAGES: Cardiac dysfunction induced during the weaning process may get masked and manifests post-extubation. Echocardiographic assessment during the weaning process and post-extubation helps to evaluate and identify the patients at risk of reintubation. HOW TO CITE THIS ARTICLE: Amarja H, Bhuvana K, Sriram S. Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process. Indian Journal of Critical Care Medicine, January 2019;23(1):15-19.
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spelling pubmed-64812672019-05-07 Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process Amarja, Havaldar Bhuvana, Krishna Sriram, Sampath Indian J Crit Care Med Original Article CONTEXT: Weaning induced cardiac dysfunction can occur without underlying heart disease. Changes in intrathoracic pressure, systemic vascular resistance, preload and afterload leading to heart-lung interactions are the possible explanatory mechanisms AIMS: The aim of the current study was whether the assessment and identification of cardiac dysfunction induced during the weaning process could predict the outcome of extubation. SETTINGS AND DESIGN: A prospective observational study with convenience sampling method was conducted from May 2015 to April 2016 after institutional ethical committee approval (ref 161/2015). MATERIALS AND METHODS: Patients over eighteen and planned for extubation were included. Weaning method used was a spontaneous breathing trial (SBT) by pressure support-positive end-expiratory pressure (PS-PEEP). Baseline characteristics, weaning, and echocardiography parameters were collected pre extubation. Post-extubation echocardiographic parameters were collected within six hours as per the protocol. The primary outcome was extubation failure (reintubation within 48 hours). Secondary outcomes were ICU length of stay and ICU mortality. STATISTICAL ANALYSIS: Statistical method used is STATA™ (Version14, College Station TX). RESULTS: Out of one hundred and sixty-one patients, twenty-one failed extubation (13.04 %). Pre-extubation echocardiographic parameters were similar in two groups except for preexisting LV systolic dysfunction. Post-extubation E/e` (9.30 vs. 7.71 p = 0.018) was higher in the extubation failure group. Extubation failure group had higher intensive care unit (ICU) length of stay and ICU mortality. CONCLUSION: In our study E/e` during a weaning trial did not predict extubation success. Cardiac dysfunction induced during weaning may get masked during weaning and manifests postextubation. This needs to be verified in subsequent studies. KEY MESSAGES: Cardiac dysfunction induced during the weaning process may get masked and manifests post-extubation. Echocardiographic assessment during the weaning process and post-extubation helps to evaluate and identify the patients at risk of reintubation. HOW TO CITE THIS ARTICLE: Amarja H, Bhuvana K, Sriram S. Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process. Indian Journal of Critical Care Medicine, January 2019;23(1):15-19. Jaypee Brothers Medical Publishers 2019-01 /pmc/articles/PMC6481267/ /pubmed/31065203 http://dx.doi.org/10.5005/jp-journals-10071-23106 Text en Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
spellingShingle Original Article
Amarja, Havaldar
Bhuvana, Krishna
Sriram, Sampath
Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process
title Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process
title_full Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process
title_fullStr Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process
title_full_unstemmed Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process
title_short Prospective Observational Study on Evaluation of Cardiac Dysfunction Induced during the Weaning Process
title_sort prospective observational study on evaluation of cardiac dysfunction induced during the weaning process
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481267/
https://www.ncbi.nlm.nih.gov/pubmed/31065203
http://dx.doi.org/10.5005/jp-journals-10071-23106
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