Cargando…
Novel N,N-dialkyl cyanocinnamic acids as monocarboxylate transporter 1 and 4 inhibitors
Potent and dual monocarboxylate transporter (MCT) 1 and 4 inhibitors have been developed for the first time as potential anticancer agents based on α-cyanocinnamic acid structural template. Candidate inhibitors 1–9 have been evaluated for in vitro cell proliferation against MCT1 and MCT4 expressing...
Autores principales: | Jonnalagadda, Shirisha, Jonnalagadda, Sravan K., Ronayne, Conor T., Nelson, Grady L., Solano, Lucas N., Rumbley, Jon, Holy, Jon, Mereddy, Venkatram R., Drewes, Lester R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481325/ https://www.ncbi.nlm.nih.gov/pubmed/31040927 http://dx.doi.org/10.18632/oncotarget.26760 |
Ejemplares similares
-
Development of Novel Silyl Cyanocinnamic Acid Derivatives as Metabolic Plasticity Inhibitors for Cancer Treatment
por: Nelson, Grady L., et al.
Publicado: (2019) -
Synthesis, in vitro, and in vivo evaluation of novel N-phenylindazolyl diarylureas as potential anti-cancer agents
por: Solano, Lucas N., et al.
Publicado: (2020) -
Development of Novel Analogs of the Monocarboxylate Transporter Ligand FACH and Biological Validation of One Potential Radiotracer for Positron Emission Tomography (PET) Imaging
por: Sadeghzadeh, Masoud, et al.
Publicado: (2020) -
Synthesis and Evaluation of Baylis-Hillman Reaction Derived Imidazole and Triazole Cinnamates as Antifungal Agents
por: Nelson, Grady L., et al.
Publicado: (2018) -
Case Report: Intra-Tumoral Vaccinations of Quadrivalent HPV-L1 Peptide Vaccine With Topical TLR-7 Agonist Following Recurrence: Complete Resolution of HPV-HR-Associated Gynecologic Squamous Cell Carcinomas in Two Patients
por: Reedy, Mark, et al.
Publicado: (2021)