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Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients
BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Phospholipids are now well-recognised players in tumour progression. Their metabolic tissue alterations can be associated with plasmatic modifications. The aim of this study was to evaluate the potential of the pla...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481329/ https://www.ncbi.nlm.nih.gov/pubmed/31040908 http://dx.doi.org/10.18632/oncotarget.26738 |
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author | Cotte, Alexia Karen Cottet, Vanessa Aires, Virginie Mouillot, Thomas Rizk, Maud Vinault, Sandrine Binquet, Christine de Barros, Jean-Paul Pais Hillon, Patrick Delmas, Dominique |
author_facet | Cotte, Alexia Karen Cottet, Vanessa Aires, Virginie Mouillot, Thomas Rizk, Maud Vinault, Sandrine Binquet, Christine de Barros, Jean-Paul Pais Hillon, Patrick Delmas, Dominique |
author_sort | Cotte, Alexia Karen |
collection | PubMed |
description | BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Phospholipids are now well-recognised players in tumour progression. Their metabolic tissue alterations can be associated with plasmatic modifications. The aim of this study was to evaluate the potential of the plasma phospholipid profile as a risk and prognostic biomarker in HCC. METHODS: Ninety cirrhotic patients with (cases) or without HCC (controls) were studied after matching for inclusion centre, age, gender, virus infection, cirrhosis duration and Child-Pugh grade. High-performance liquid chromatography coupled with tandem-mass spectrometry was used to quantify the main species of seven categories of phospholipids in plasma. RESULTS: Elevated concentrations of phosphatidylcholine (PC) 16:0/16:1 (p=0.0180), PC 16:0/16:0 (p=0.0327), PC 16:0/18:1 (p=0.0264) and sphingomyelin (SM) 18:2/24:1 (p=0.0379) and low concentrations of lysophosphatidylcholine 20:4 (0.0093) and plasmalogen-phosphatidylethanolamine (pPE) 16:0/20:4 (p=0.0463), pPE 18:0/20:4 (p=0.0077), pPE 18:0/20:5 (p=0.0163), pPE 18:0/20:3 (p=0.0463) discriminated HCC patients from cirrhotic controls. Two ceramide species were associated with increased HCC risk of death while lysophospholipids, a polyunsaturated phosphatidylinositol, some PC and SM species were associated with low risk of death in HCC patients in 1 and/or 3 years. CONCLUSION: This study identified phospholipid profiles related to HCC risk in liver cirrhotic patients and showed for the first time the potential of some phospholipids in predicting HCC patient mortality. |
format | Online Article Text |
id | pubmed-6481329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-64813292019-04-30 Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients Cotte, Alexia Karen Cottet, Vanessa Aires, Virginie Mouillot, Thomas Rizk, Maud Vinault, Sandrine Binquet, Christine de Barros, Jean-Paul Pais Hillon, Patrick Delmas, Dominique Oncotarget Research Paper BACKGROUND: Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Phospholipids are now well-recognised players in tumour progression. Their metabolic tissue alterations can be associated with plasmatic modifications. The aim of this study was to evaluate the potential of the plasma phospholipid profile as a risk and prognostic biomarker in HCC. METHODS: Ninety cirrhotic patients with (cases) or without HCC (controls) were studied after matching for inclusion centre, age, gender, virus infection, cirrhosis duration and Child-Pugh grade. High-performance liquid chromatography coupled with tandem-mass spectrometry was used to quantify the main species of seven categories of phospholipids in plasma. RESULTS: Elevated concentrations of phosphatidylcholine (PC) 16:0/16:1 (p=0.0180), PC 16:0/16:0 (p=0.0327), PC 16:0/18:1 (p=0.0264) and sphingomyelin (SM) 18:2/24:1 (p=0.0379) and low concentrations of lysophosphatidylcholine 20:4 (0.0093) and plasmalogen-phosphatidylethanolamine (pPE) 16:0/20:4 (p=0.0463), pPE 18:0/20:4 (p=0.0077), pPE 18:0/20:5 (p=0.0163), pPE 18:0/20:3 (p=0.0463) discriminated HCC patients from cirrhotic controls. Two ceramide species were associated with increased HCC risk of death while lysophospholipids, a polyunsaturated phosphatidylinositol, some PC and SM species were associated with low risk of death in HCC patients in 1 and/or 3 years. CONCLUSION: This study identified phospholipid profiles related to HCC risk in liver cirrhotic patients and showed for the first time the potential of some phospholipids in predicting HCC patient mortality. Impact Journals LLC 2019-03-15 /pmc/articles/PMC6481329/ /pubmed/31040908 http://dx.doi.org/10.18632/oncotarget.26738 Text en Copyright: © 2019 Cotte et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Cotte, Alexia Karen Cottet, Vanessa Aires, Virginie Mouillot, Thomas Rizk, Maud Vinault, Sandrine Binquet, Christine de Barros, Jean-Paul Pais Hillon, Patrick Delmas, Dominique Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients |
title | Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients |
title_full | Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients |
title_fullStr | Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients |
title_full_unstemmed | Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients |
title_short | Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients |
title_sort | phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481329/ https://www.ncbi.nlm.nih.gov/pubmed/31040908 http://dx.doi.org/10.18632/oncotarget.26738 |
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