Cargando…

A novel anti-melanoma SRC-family kinase inhibitor

The major drawback of melanoma therapy with BRAF and MAPK inhibitors is the innate and acquired drug resistance. We therefore explored alternative targets and developed a new compound, SAB298, that is a SRC-family kinase (SFK) inhibitor. The drug is cytotoxic to patient-derived melanoma cells regard...

Descripción completa

Detalles Bibliográficos
Autores principales:	Halaban, Ruth, Bacchiocchi, Antonella, Straub, Robert, Cao, Jian, Sznol, Mario, Narayan, Deepak, Allam, Ahmed, Krauthammer, Michael, Mansour, Tarek S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481345/ https://www.ncbi.nlm.nih.gov/pubmed/31040916 http://dx.doi.org/10.18632/oncotarget.26787

Ejemplares similares

PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF(WT) melanoma cells
por: Halaban, Ruth, et al.
Publicado: (2010)

Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032
por: Rubinstein, Jill C, et al.
Publicado: (2010)

Integrative Analysis of Epigenetic Modulation in Melanoma Cell Response to Decitabine: Clinical Implications
por: Halaban, Ruth, et al.
Publicado: (2009)

Spitz nevi and Spitzoid melanomas - Exome sequencing and comparison to conventional melanocytic nevi and melanomas
por: Lazova, Rossitza, et al.
Publicado: (2017)

Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma
por: Rubinstein, Jill C, et al.
Publicado: (2010)

Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
por: Choi, Jaehyuk, et al.
Publicado: (2014)

Detecting copy number status and uncovering subclonal markers in heterogeneous tumor biopsies
por: Parisi, Fabio, et al.
Publicado: (2011)

A Variant in a MicroRNA Complementary Site in the 3′UTR of the KIT Oncogene Increases Risk of Acral Melanoma
por: Godshalk, Sirie E., et al.
Publicado: (2010)

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
por: Krauthammer, Michael, et al.
Publicado: (2012)

Optimization of Aminoimidazole Derivatives as Src Family Kinase Inhibitors
por: Francini, Cinzia Maria, et al.
Publicado: (2018)

Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis
por: Manocha, Gunjan D., et al.
Publicado: (2015)

Integrated Analysis of Tumor Samples Sheds Light on Tumor Heterogeneity
por: Parisi, Fabio, et al.
Publicado: (2012)

Pre-treatment patient selection for nivolumab benefit based on serum mass spectra
por: Weber, Jeffrey, et al.
Publicado: (2015)

Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis
por: Farshidfar, Farshad, et al.
Publicado: (2022)

Structure and Characterization of a Covalent Inhibitor of Src Kinase
por: Gurbani, Deepak, et al.
Publicado: (2020)

Author Correction: Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis
por: Farshidfar, Farshad, et al.
Publicado: (2022)

Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines
por: Eustace, Alex J, et al.
Publicado: (2008)

Regulation of the Src Family Kinases by Csk
por: Okada, Masato
Publicado: (2012)

Divergent Modulation of Src-Family Kinase Regulatory Interactions with ATP-Competitive Inhibitors
por: Leonard, Stephen E., et al.
Publicado: (2014)

Targeting autophagy sensitises lung cancer cells to Src family kinase inhibitors
por: Rupniewska, Ewa, et al.
Publicado: (2018)

Src Family Kinase Inhibitors Block Translation of Alphavirus Subgenomic mRNAs
por: Broeckel, Rebecca, et al.
Publicado: (2019)

The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling
por: Ichikawa-Tomikawa, Naoki, et al.
Publicado: (2023)

Regulation of Src Family Kinases in Human Cancers
por: Sen, Banibrata, et al.
Publicado: (2011)

The Role of Src Family Kinases in Prostate Cancer
por: Tatarov, Oleg, et al.
Publicado: (2007)

Phosphorylation of unique domains of Src family kinases
por: Amata, Irene, et al.
Publicado: (2014)

Fueling the fire: Src family kinases drive inflammation
por: Ley, Klaus
Publicado: (2014)

Targeting SRC Family Kinases in Mesothelioma: Time to Upgrade
por: Indovina, Paola, et al.
Publicado: (2020)

SRC-Family Kinases in Acute Myeloid Leukaemia and Mastocytosis
por: Voisset, Edwige, et al.
Publicado: (2020)

Episodic Src activation in uveal melanoma revealed by kinase activity profiling
por: Maat, W, et al.
Publicado: (2009)

CXCR7 promotes melanoma tumorigenesis via Src kinase signaling
por: Xu, Siran, et al.
Publicado: (2019)

HOXC11–SRC-1 regulation of S100beta in cutaneous melanoma: new targets for the kinase inhibitor dasatinib
por: deBlacam, C, et al.
Publicado: (2011)

Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5
por: Chen, Yanran, et al.
Publicado: (2023)

Germline MC1R status influences somatic mutation burden in melanoma
por: Robles-Espinoza, Carla Daniela, et al.
Publicado: (2016)

Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
por: Scales, Timothy ME, et al.
Publicado: (2011)

Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis
por: Sirvent, Audrey, et al.
Publicado: (2020)

Platelet Src family kinases: A tale of reversible phosphorylation
por: Senis, Yotis A., et al.
Publicado: (2021)

Src-Family Protein Kinase Inhibitors Suppress MYB Activity in a p300-Dependent Manner
por: Biyanee, Abhiruchi, et al.
Publicado: (2022)

Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies
por: Winiarska, Magdalena, et al.
Publicado: (2014)

Deregulated E2f Transcriptional Activity in Autonomously Growing Melanoma Cells
por: Halaban, Ruth, et al.
Publicado: (2000)

TCR-independent Activation in Presence of a Src-family Kinase Inhibitor Improves CAR-T Cell Product Attributes
por: Lamture, Gauri, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_01a0iri8cte983ntuj9areopig