Cargando…

NFATc3 plays an oncogenic role in oral/oropharyngeal squamous cell carcinomas by promoting cancer stemness via expression of OCT4

Nuclear factor of activated T cells (NFATc1-c4), a family of transcription factors, is involved in many biological processes by regulating various downstream target genes. However, their role in cancer progression remains controversial. We here report that NFATc3 is the dominant isoform of NFAT in h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Sung Hee, Kieu, Calvin, Martin, Charlotte Ellen, Han, Jiho, Chen, Wei, Kim, Jin Seok, Kang, Mo K., Kim, Reuben H., Park, No-Hee, Kim, Yong, Shin, Ki-Hyuk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481346/ https://www.ncbi.nlm.nih.gov/pubmed/31040921 http://dx.doi.org/10.18632/oncotarget.26774

Ejemplares similares

Chronic Alcohol Exposure Promotes Cancer Stemness and Glycolysis in Oral/Oropharyngeal Squamous Cell Carcinoma Cell Lines by Activating NFAT Signaling
por: Nguyen, Anthony, et al.
Publicado: (2022)

Orai1 promotes tumor progression by enhancing cancer stemness via NFAT signaling in oral/oropharyngeal squamous cell carcinoma
por: Lee, Sung Hee, et al.
Publicado: (2016)

Orai3 Calcium Channel Contributes to Oral/Oropharyngeal Cancer Stemness through the Elevation of ID1 Expression
por: Nguyen, Anthony, et al.
Publicado: (2023)

Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation
por: Hee Lee, Sung, et al.
Publicado: (2015)

Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1
por: Song, Min-Kyoung, et al.
Publicado: (2015)

Regulation of NFATc1 in Osteoclast Differentiation
por: Kim, Jung Ha, et al.
Publicado: (2014)

Gα12 regulates osteoclastogenesis by modulating NFATc1 expression
por: Song, Min‐Kyoung, et al.
Publicado: (2017)

EWS-Oct-4B, an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours
por: Kim, S, et al.
Publicado: (2010)

Chaenomelis fructus inhibits osteoclast differentiation by suppressing NFATc1 expression and prevents ovariectomy-induced osteoporosis
por: Kim, Minsun, et al.
Publicado: (2020)

Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes
por: Lee, Rachel S., et al.
Publicado: (2017)

Proinflammatory cytokine TNFα promotes HPV-associated oral carcinogenesis by increasing cancer stemness
por: Hong, Hannah S., et al.
Publicado: (2020)

The Role of NFATC4 Gene in Human Cutaneous Squamous Cell Carcinoma
por: Li, Fengjuan, et al.
Publicado: (2023)

NFATC1 and NFATC2 expression patterns in human osteochondromas
por: Wang, Yuanyuan, et al.
Publicado: (2023)

NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4(+) T lymphocytes by CD4(+) CD25(+) regulatory T cells
por: Bopp, Tobias, et al.
Publicado: (2005)

Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D, and GRHL2 in human oral squamous cell carcinoma cells
por: Kang, Xuedong, et al.
Publicado: (2008)

Rosiglitazone suppresses RANKL‐induced NFATc1 autoamplification by disrupting the physical interaction between NFATc1 and PPARγ
por: Park, Kyeong‐Lok, et al.
Publicado: (2018)

RCANs regulate the convergent roles of NFATc1 in bone homeostasis
por: Kim, Jung Ha, et al.
Publicado: (2016)

Clinical Practice Guidelines for Oropharyngeal Dysphagia
por: Yang, Seoyon, et al.
Publicado: (2023)

Carboxyl-Terminal Modulator Protein Positively Acts as an Oncogenic Driver in Head and Neck Squamous Cell Carcinoma via Regulating Akt phosphorylation
por: Chang, Jae Won, et al.
Publicado: (2016)

Low Survival Rates of Oral and Oropharyngeal Squamous Cell Carcinoma
por: Le Campion, Anna Carolina Omena Vasconcellos, et al.
Publicado: (2017)

Microbial Signatures Associated with Oropharyngeal and Oral Squamous Cell Carcinomas
por: Banerjee, Sagarika, et al.
Publicado: (2017)

Ultrasensitive detection of oncogenic human papillomavirus in oropharyngeal tissue swabs
por: Isaac, Andre, et al.
Publicado: (2017)

Molecular genetic characterization of p53 mutated oropharyngeal squamous cell carcinoma cells transformed with human papillomavirus E6 and E7 oncogenes
por: OH, JI-EUN, et al.
Publicado: (2013)

Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness
por: Kim, Gi-Cheon, et al.
Publicado: (2018)

Promoter Hypermethylation Promotes the Binding of Transcription Factor NFATc1, Triggering Oncogenic Gene Activation in Pancreatic Cancer
por: Wu, Yenan, et al.
Publicado: (2021)

CIP2A is an Oct4 target gene involved in head and neck squamous cell cancer oncogenicity and radioresistance
por: Ventelä, Sami, et al.
Publicado: (2014)

Current status of clinical testing for human papillomavirus in oropharyngeal squamous cell carcinoma
por: Kim, Kelly Y, et al.
Publicado: (2018)

TCF/β-catenin plays an important role in HCCR-1 oncogene expression
por: Cho, Goang-Won, et al.
Publicado: (2009)

Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 2: Human papillomavirus associated oral and oropharyngeal squamous cell carcinoma
por: Feller, Liviu, et al.
Publicado: (2010)

Gleditsiae fructus regulates osteoclastogenesis by inhibiting the c‑Fos/NFATc1 pathway and alleviating bone loss in an ovariectomy model
por: Cho, Chang-Young, et al.
Publicado: (2023)

Inhibition of RANKL-stimulated osteoclast differentiation by Schisandra chinensis through down-regulation of NFATc1 and c-fos expression
por: Kim, Eun-Jung, et al.
Publicado: (2018)

Ectopic Hepatocellular Carcinoma Arising from the Peritoneum in a Patient with a History of Oropharyngeal Cancer: A Case Report
por: Lee, Ji Young, et al.
Publicado: (2015)

Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors
por: van Kempen, Pauline M. W., et al.
Publicado: (2016)

The Role of Ca(2+)-NFATc1 Signaling and Its Modulation on Osteoclastogenesis
por: Kang, Jung Yun, et al.
Publicado: (2020)

Clinical features of oral and oropharyngeal squamous cell carcinoma HPV related
por: Azevedo, Pedro Leite, et al.
Publicado: (2014)

TRH site-specific methylation in oral and oropharyngeal squamous cell carcinoma
por: Puttipanyalears, C., et al.
Publicado: (2018)

Evaluation of p16 expression in oral and oropharyngeal squamous cell carcinoma
por: Saxena, Pallavi, et al.
Publicado: (2022)

hTERT peptide fragment GV1001 demonstrates radioprotective and antifibrotic effects through suppression of TGF-β signaling
por: Chen, Wei, et al.
Publicado: (2018)

An Update on the Immunotherapy for Oropharyngeal Squamous Cell Carcinoma
por: Huang, Yaxuan, et al.
Publicado: (2022)

Retropharyngeal lymph node-sparing radiotherapy in patients with oropharyngeal carcinoma
por: Kang, Byung-Hee, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hip2fjae362etlf96gdsdflsdh