Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function

Apolipoprotein (apo) E4, the major genetic risk factor for Alzheimer’s disease (AD), alters mitochondrial function and metabolism early in AD pathogenesis. When injured or stressed, neurons increase apoE synthesis. Because of its structural difference from apoE3, apoE4 undergoes neuron-specific prot...

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Detalles Bibliográficos
Autores principales: Orr, Adam L., Kim, Chaeyoung, Jimenez-Morales, David, Newton, Billy W., Johnson, Jeffrey R., Krogan, Nevan J., Swaney, Danielle L., Mahley, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481541/
https://www.ncbi.nlm.nih.gov/pubmed/30883359
http://dx.doi.org/10.3233/JAD-181184

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