The Tandem Duplicator Phenotype Is a Prevalent Genome-Wide Cancer Configuration Driven by Distinct Gene Mutations

The tandem duplicator phenotype (TDP) is a genome-wide instability configuration primarily observed in breast, ovarian, and endometrial carcinomas. Here, we stratify TDP tumors by classifying their tandem duplications (TDs) into three span intervals, with modal values of 11 kb, 231 kb, and 1.7 Mb, r...

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Detalles Bibliográficos
Autores principales: Menghi, Francesca, Barthel, Floris P., Yadav, Vinod, Tang, Ming, Ji, Bo, Tang, Zhonghui, Carter, Gregory W., Ruan, Yijun, Scully, Ralph, Verhaak, Roel G.W., Jonkers, Jos, Liu, Edison T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481635/
https://www.ncbi.nlm.nih.gov/pubmed/30017478
http://dx.doi.org/10.1016/j.ccell.2018.06.008

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