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Review: Multimodal bioactive material approaches for wound healing

Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collage...

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Detalles Bibliográficos
Autores principales: Mandla, Serena, Davenport Huyer, Locke, Radisic, Milica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AIP Publishing LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481710/
https://www.ncbi.nlm.nih.gov/pubmed/31069297
http://dx.doi.org/10.1063/1.5026773
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author Mandla, Serena
Davenport Huyer, Locke
Radisic, Milica
author_facet Mandla, Serena
Davenport Huyer, Locke
Radisic, Milica
author_sort Mandla, Serena
collection PubMed
description Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collagen wound dressings, are unable to meet the demand set by the wound environment. Therefore, a multifaceted bioactive dressing is needed to elicit a targeted affect. Wound healing strategies seek to develop a targeted effect through the delivery of a bioactive molecule to the wound by a hydrogel or a polymeric scaffold. This review examines current biomaterial and small molecule-based approaches that seek to develop a bioactive material for targeted wound therapy and accepted wound healing models for testing material efficacy.
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spelling pubmed-64817102019-05-08 Review: Multimodal bioactive material approaches for wound healing Mandla, Serena Davenport Huyer, Locke Radisic, Milica APL Bioeng Reviews Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collagen wound dressings, are unable to meet the demand set by the wound environment. Therefore, a multifaceted bioactive dressing is needed to elicit a targeted affect. Wound healing strategies seek to develop a targeted effect through the delivery of a bioactive molecule to the wound by a hydrogel or a polymeric scaffold. This review examines current biomaterial and small molecule-based approaches that seek to develop a bioactive material for targeted wound therapy and accepted wound healing models for testing material efficacy. AIP Publishing LLC 2018-06-26 /pmc/articles/PMC6481710/ /pubmed/31069297 http://dx.doi.org/10.1063/1.5026773 Text en © 2018 Author(s). 2473-2877/2018/2(2)/021503/13 All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Reviews
Mandla, Serena
Davenport Huyer, Locke
Radisic, Milica
Review: Multimodal bioactive material approaches for wound healing
title Review: Multimodal bioactive material approaches for wound healing
title_full Review: Multimodal bioactive material approaches for wound healing
title_fullStr Review: Multimodal bioactive material approaches for wound healing
title_full_unstemmed Review: Multimodal bioactive material approaches for wound healing
title_short Review: Multimodal bioactive material approaches for wound healing
title_sort review: multimodal bioactive material approaches for wound healing
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481710/
https://www.ncbi.nlm.nih.gov/pubmed/31069297
http://dx.doi.org/10.1063/1.5026773
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