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Review: Multimodal bioactive material approaches for wound healing
Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collage...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AIP Publishing LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481710/ https://www.ncbi.nlm.nih.gov/pubmed/31069297 http://dx.doi.org/10.1063/1.5026773 |
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author | Mandla, Serena Davenport Huyer, Locke Radisic, Milica |
author_facet | Mandla, Serena Davenport Huyer, Locke Radisic, Milica |
author_sort | Mandla, Serena |
collection | PubMed |
description | Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collagen wound dressings, are unable to meet the demand set by the wound environment. Therefore, a multifaceted bioactive dressing is needed to elicit a targeted affect. Wound healing strategies seek to develop a targeted effect through the delivery of a bioactive molecule to the wound by a hydrogel or a polymeric scaffold. This review examines current biomaterial and small molecule-based approaches that seek to develop a bioactive material for targeted wound therapy and accepted wound healing models for testing material efficacy. |
format | Online Article Text |
id | pubmed-6481710 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | AIP Publishing LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-64817102019-05-08 Review: Multimodal bioactive material approaches for wound healing Mandla, Serena Davenport Huyer, Locke Radisic, Milica APL Bioeng Reviews Wound healing is a highly complex process of tissue repair that relies on the synergistic effect of a number of different cells, cytokines, enzymes, and growth factors. A deregulation in this process can lead to the formation of a non-healing chronic ulcer. Current treatment options, such as collagen wound dressings, are unable to meet the demand set by the wound environment. Therefore, a multifaceted bioactive dressing is needed to elicit a targeted affect. Wound healing strategies seek to develop a targeted effect through the delivery of a bioactive molecule to the wound by a hydrogel or a polymeric scaffold. This review examines current biomaterial and small molecule-based approaches that seek to develop a bioactive material for targeted wound therapy and accepted wound healing models for testing material efficacy. AIP Publishing LLC 2018-06-26 /pmc/articles/PMC6481710/ /pubmed/31069297 http://dx.doi.org/10.1063/1.5026773 Text en © 2018 Author(s). 2473-2877/2018/2(2)/021503/13 All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Reviews Mandla, Serena Davenport Huyer, Locke Radisic, Milica Review: Multimodal bioactive material approaches for wound healing |
title | Review: Multimodal bioactive material approaches for wound healing |
title_full | Review: Multimodal bioactive material approaches for wound healing |
title_fullStr | Review: Multimodal bioactive material approaches for wound healing |
title_full_unstemmed | Review: Multimodal bioactive material approaches for wound healing |
title_short | Review: Multimodal bioactive material approaches for wound healing |
title_sort | review: multimodal bioactive material approaches for wound healing |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481710/ https://www.ncbi.nlm.nih.gov/pubmed/31069297 http://dx.doi.org/10.1063/1.5026773 |
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