Rationally engineered advances in cancer research

The physical and engineering sciences have much to offer in understanding, diagnosing, and even treating cancer. Microfluidics, imaging, materials, and diverse measurement devices are all helping to shift paradigms of tumorigenesis and dissemination. Using materials and micro-probes of elasticity, for example, epithelia have been shown to transform into mesenchymal cells when the elasticity of adjacent tissue increases. Approaches common in engineering science enable such discoveries, and further application of such tools and principles will likely improve existing cancer models in vivo and also create better models for high throughput analyses in vitro. As profiled in this special topic issue composed of more than a dozen manuscripts, opportunities abound for the creativity and analytics of engineering and the physical sciences to make advances in and against cancer.