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Non-steric-zipper models for pathogenic α-synuclein conformers

Parkinson's disease neurodegenerative brain tissue exhibits two biophysically distinct α-synuclein fiber isoforms—single stranded fibers that appear to be steric-zippers and double-stranded fibers with an undetermined structure. Herein, we describe a β-helical homology model of α-synuclein that...

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Detalles Bibliográficos
Autores principales:	Schuman, Brock, Won, Amy, Brand-Arzamendi, Koroboshka, Koprich, James B., Wen, Xiao-Yan, Howson, Patrick A., Brotchie, Jonathan M., Yip, Christopher M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AIP Publishing LLC 2018
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481714/ https://www.ncbi.nlm.nih.gov/pubmed/31069302 http://dx.doi.org/10.1063/1.5023460

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