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Plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep
Plasma pharmacokinetic profiles and the anti-inflammatory efficacy of meloxicam were determined when administered subcutaneously (SC) or intramuscularly (IM) to sheep. Merino ewes were initially injected with 0.1 mL of oil of turpentine into a forelimb to induce inflammation, followed by either 1.0...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481916/ https://www.ncbi.nlm.nih.gov/pubmed/31017959 http://dx.doi.org/10.1371/journal.pone.0215842 |
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author | Woodland, Alyssa N. Van der Saag, Dominique Kimble, Benjamin White, Peter J. Govendir, Merran Lomax, Sabrina |
author_facet | Woodland, Alyssa N. Van der Saag, Dominique Kimble, Benjamin White, Peter J. Govendir, Merran Lomax, Sabrina |
author_sort | Woodland, Alyssa N. |
collection | PubMed |
description | Plasma pharmacokinetic profiles and the anti-inflammatory efficacy of meloxicam were determined when administered subcutaneously (SC) or intramuscularly (IM) to sheep. Merino ewes were initially injected with 0.1 mL of oil of turpentine into a forelimb to induce inflammation, followed by either 1.0 mg/kg or 2.0 mg/kg of meloxicam administered either SC or IM (n = 6 per treatment group) or followed by no meloxicam administration (control) (n = 4). Ewes were examined to determine skin temperature, limb circumference, limb sensitivity and signs of lameness at 0, 0.5, 1, 2, 4, 6, 8, 10, 12, 24 and 48 h following treatment, with blood collected at these time-points to quantify meloxicam plasma concentrations. Skin temperature of ewes dosed with meloxicam at 1.0 mg/kg SC and 2.0 mg/kg IM at 12 h and 1.0 mg/kg SC at 24 were significantly different to the controls (P < 0.05). Limb circumferences of ewes dosed with 1.0 mg/kg IM were significantly different to controls at 10 h and 12 h (P < 0.05). All meloxicam treatment groups resulted in reduced limb sensitivity compared to controls at 6 h, with the 1.0 and 2.0 mg/kg IM treatments significantly different at 12 h (P < 0.05) and 1.0 and 2.0 mg/kg SC groups, significantly different to controls at 48 h (P < 0.05). No significant difference in lameness scores were detected over 48 h. The 1.0 mg/kg IM treatment had a significantly greater plasma meloxicam concentration than the 1.0 mg/kg SC treatment over 0.5 to 4 h (P < 0.001). Both 1.0 mg/kg SC and IM treatments demonstrated elimination half-lives (mean ± SD) of 10.82 ± 2.46 and 12.63 ± 2.37 h, respectively. Meloxicam at all doses provided some anti-inflammatory and analgesic effects from 6 to 48 h; however no route could be distinguished as more efficacious than the others. |
format | Online Article Text |
id | pubmed-6481916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-64819162019-05-07 Plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep Woodland, Alyssa N. Van der Saag, Dominique Kimble, Benjamin White, Peter J. Govendir, Merran Lomax, Sabrina PLoS One Research Article Plasma pharmacokinetic profiles and the anti-inflammatory efficacy of meloxicam were determined when administered subcutaneously (SC) or intramuscularly (IM) to sheep. Merino ewes were initially injected with 0.1 mL of oil of turpentine into a forelimb to induce inflammation, followed by either 1.0 mg/kg or 2.0 mg/kg of meloxicam administered either SC or IM (n = 6 per treatment group) or followed by no meloxicam administration (control) (n = 4). Ewes were examined to determine skin temperature, limb circumference, limb sensitivity and signs of lameness at 0, 0.5, 1, 2, 4, 6, 8, 10, 12, 24 and 48 h following treatment, with blood collected at these time-points to quantify meloxicam plasma concentrations. Skin temperature of ewes dosed with meloxicam at 1.0 mg/kg SC and 2.0 mg/kg IM at 12 h and 1.0 mg/kg SC at 24 were significantly different to the controls (P < 0.05). Limb circumferences of ewes dosed with 1.0 mg/kg IM were significantly different to controls at 10 h and 12 h (P < 0.05). All meloxicam treatment groups resulted in reduced limb sensitivity compared to controls at 6 h, with the 1.0 and 2.0 mg/kg IM treatments significantly different at 12 h (P < 0.05) and 1.0 and 2.0 mg/kg SC groups, significantly different to controls at 48 h (P < 0.05). No significant difference in lameness scores were detected over 48 h. The 1.0 mg/kg IM treatment had a significantly greater plasma meloxicam concentration than the 1.0 mg/kg SC treatment over 0.5 to 4 h (P < 0.001). Both 1.0 mg/kg SC and IM treatments demonstrated elimination half-lives (mean ± SD) of 10.82 ± 2.46 and 12.63 ± 2.37 h, respectively. Meloxicam at all doses provided some anti-inflammatory and analgesic effects from 6 to 48 h; however no route could be distinguished as more efficacious than the others. Public Library of Science 2019-04-24 /pmc/articles/PMC6481916/ /pubmed/31017959 http://dx.doi.org/10.1371/journal.pone.0215842 Text en © 2019 Woodland et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Woodland, Alyssa N. Van der Saag, Dominique Kimble, Benjamin White, Peter J. Govendir, Merran Lomax, Sabrina Plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep |
title | Plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep |
title_full | Plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep |
title_fullStr | Plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep |
title_full_unstemmed | Plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep |
title_short | Plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep |
title_sort | plasma pharmacokinetic profile and efficacy of meloxicam administered subcutaneously and intramuscularly to sheep |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481916/ https://www.ncbi.nlm.nih.gov/pubmed/31017959 http://dx.doi.org/10.1371/journal.pone.0215842 |
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