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Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation
The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage–specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative state toward quiescence. How metabolic and cell-cycle sta...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481923/ https://www.ncbi.nlm.nih.gov/pubmed/30978178 http://dx.doi.org/10.1371/journal.pbio.2006506 |
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author | Ferreirós-Vidal, Isabel Carroll, Thomas Zhang, Tianyi Lagani, Vincenzo Ramirez, Ricardo N. Ing-Simmons, Elizabeth Gómez-Valadés, Alicia G. Cooper, Lee Liang, Ziwei Papoutsoglou, Georgios Dharmalingam, Gopuraja Guo, Ya Tarazona, Sonia Fernandes, Sunjay J. Noori, Peri Silberberg, Gilad Fisher, Amanda G. Tsamardinos, Ioannis Mortazavi, Ali Lenhard, Boris Conesa, Ana Tegner, Jesper Merkenschlager, Matthias Gomez-Cabrero, David |
author_facet | Ferreirós-Vidal, Isabel Carroll, Thomas Zhang, Tianyi Lagani, Vincenzo Ramirez, Ricardo N. Ing-Simmons, Elizabeth Gómez-Valadés, Alicia G. Cooper, Lee Liang, Ziwei Papoutsoglou, Georgios Dharmalingam, Gopuraja Guo, Ya Tarazona, Sonia Fernandes, Sunjay J. Noori, Peri Silberberg, Gilad Fisher, Amanda G. Tsamardinos, Ioannis Mortazavi, Ali Lenhard, Boris Conesa, Ana Tegner, Jesper Merkenschlager, Matthias Gomez-Cabrero, David |
author_sort | Ferreirós-Vidal, Isabel |
collection | PubMed |
description | The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage–specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative state toward quiescence. How metabolic and cell-cycle states are coordinated with the regulation of cell type–specific genes is an important question, because dissociation between differentiation, cell cycle, and metabolic states is a hallmark of cancer. Here, we use a model system to systematically identify key transcriptional regulators of Ikaros-dependent B cell–progenitor differentiation. We find that the coordinated regulation of housekeeping functions and tissue-specific gene expression requires a feedforward circuit whereby Ikaros down-regulates the expression of Myc. Our findings show how coordination between differentiation and housekeeping states can be achieved by interconnected regulators. Similar principles likely coordinate differentiation and housekeeping functions during progenitor cell differentiation in other cell lineages. |
format | Online Article Text |
id | pubmed-6481923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-64819232019-05-07 Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation Ferreirós-Vidal, Isabel Carroll, Thomas Zhang, Tianyi Lagani, Vincenzo Ramirez, Ricardo N. Ing-Simmons, Elizabeth Gómez-Valadés, Alicia G. Cooper, Lee Liang, Ziwei Papoutsoglou, Georgios Dharmalingam, Gopuraja Guo, Ya Tarazona, Sonia Fernandes, Sunjay J. Noori, Peri Silberberg, Gilad Fisher, Amanda G. Tsamardinos, Ioannis Mortazavi, Ali Lenhard, Boris Conesa, Ana Tegner, Jesper Merkenschlager, Matthias Gomez-Cabrero, David PLoS Biol Research Article The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage–specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative state toward quiescence. How metabolic and cell-cycle states are coordinated with the regulation of cell type–specific genes is an important question, because dissociation between differentiation, cell cycle, and metabolic states is a hallmark of cancer. Here, we use a model system to systematically identify key transcriptional regulators of Ikaros-dependent B cell–progenitor differentiation. We find that the coordinated regulation of housekeeping functions and tissue-specific gene expression requires a feedforward circuit whereby Ikaros down-regulates the expression of Myc. Our findings show how coordination between differentiation and housekeeping states can be achieved by interconnected regulators. Similar principles likely coordinate differentiation and housekeeping functions during progenitor cell differentiation in other cell lineages. Public Library of Science 2019-04-12 /pmc/articles/PMC6481923/ /pubmed/30978178 http://dx.doi.org/10.1371/journal.pbio.2006506 Text en © 2019 Ferreirós-Vidal et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ferreirós-Vidal, Isabel Carroll, Thomas Zhang, Tianyi Lagani, Vincenzo Ramirez, Ricardo N. Ing-Simmons, Elizabeth Gómez-Valadés, Alicia G. Cooper, Lee Liang, Ziwei Papoutsoglou, Georgios Dharmalingam, Gopuraja Guo, Ya Tarazona, Sonia Fernandes, Sunjay J. Noori, Peri Silberberg, Gilad Fisher, Amanda G. Tsamardinos, Ioannis Mortazavi, Ali Lenhard, Boris Conesa, Ana Tegner, Jesper Merkenschlager, Matthias Gomez-Cabrero, David Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation |
title | Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation |
title_full | Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation |
title_fullStr | Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation |
title_full_unstemmed | Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation |
title_short | Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation |
title_sort | feedforward regulation of myc coordinates lineage-specific with housekeeping gene expression during b cell progenitor cell differentiation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481923/ https://www.ncbi.nlm.nih.gov/pubmed/30978178 http://dx.doi.org/10.1371/journal.pbio.2006506 |
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