Cargando…

Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study

BACKGROUND: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the g...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Changhyun, Yun, Hae-Ryong, Joo, Young Su, Lee, Sangmi, Kim, Joohwan, Nam, Ki Heon, Jhee, Jong Hyun, Park, Jung Tak, Yoo, Tae-Hyun, Kang, Shin-Wook, Han, Seung Hyeok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Nephrology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481968/
https://www.ncbi.nlm.nih.gov/pubmed/30897893
http://dx.doi.org/10.23876/j.krcp.18.0118
_version_ 1783413811513917440
author Lee, Changhyun
Yun, Hae-Ryong
Joo, Young Su
Lee, Sangmi
Kim, Joohwan
Nam, Ki Heon
Jhee, Jong Hyun
Park, Jung Tak
Yoo, Tae-Hyun
Kang, Shin-Wook
Han, Seung Hyeok
author_facet Lee, Changhyun
Yun, Hae-Ryong
Joo, Young Su
Lee, Sangmi
Kim, Joohwan
Nam, Ki Heon
Jhee, Jong Hyun
Park, Jung Tak
Yoo, Tae-Hyun
Kang, Shin-Wook
Han, Seung Hyeok
author_sort Lee, Changhyun
collection PubMed
description BACKGROUND: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. METHODS: This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low- (< 10%), intermediate- (10–20%), and high- (> 20%) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m(2)). RESULTS: During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3%), 217 (10.8%), and 205 (16.9%) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high- and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197–3.255) and 1.734 (95% CI, 1.447–2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. CONCLUSION: The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function.
format Online
Article
Text
id pubmed-6481968
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Korean Society of Nephrology
record_format MEDLINE/PubMed
spelling pubmed-64819682019-05-07 Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study Lee, Changhyun Yun, Hae-Ryong Joo, Young Su Lee, Sangmi Kim, Joohwan Nam, Ki Heon Jhee, Jong Hyun Park, Jung Tak Yoo, Tae-Hyun Kang, Shin-Wook Han, Seung Hyeok Kidney Res Clin Pract Original Article BACKGROUND: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. METHODS: This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low- (< 10%), intermediate- (10–20%), and high- (> 20%) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m(2)). RESULTS: During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3%), 217 (10.8%), and 205 (16.9%) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high- and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197–3.255) and 1.734 (95% CI, 1.447–2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. CONCLUSION: The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function. Korean Society of Nephrology 2019-03 2019-03-31 /pmc/articles/PMC6481968/ /pubmed/30897893 http://dx.doi.org/10.23876/j.krcp.18.0118 Text en Copyright © 2019 by The Korean Society of Nephrology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lee, Changhyun
Yun, Hae-Ryong
Joo, Young Su
Lee, Sangmi
Kim, Joohwan
Nam, Ki Heon
Jhee, Jong Hyun
Park, Jung Tak
Yoo, Tae-Hyun
Kang, Shin-Wook
Han, Seung Hyeok
Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study
title Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study
title_full Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study
title_fullStr Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study
title_full_unstemmed Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study
title_short Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study
title_sort framingham risk score and risk of incident chronic kidney disease: a community-based prospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481968/
https://www.ncbi.nlm.nih.gov/pubmed/30897893
http://dx.doi.org/10.23876/j.krcp.18.0118
work_keys_str_mv AT leechanghyun framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy
AT yunhaeryong framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy
AT jooyoungsu framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy
AT leesangmi framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy
AT kimjoohwan framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy
AT namkiheon framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy
AT jheejonghyun framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy
AT parkjungtak framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy
AT yootaehyun framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy
AT kangshinwook framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy
AT hanseunghyeok framinghamriskscoreandriskofincidentchronickidneydiseaseacommunitybasedprospectivecohortstudy