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Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study
BACKGROUND: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the g...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Nephrology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481968/ https://www.ncbi.nlm.nih.gov/pubmed/30897893 http://dx.doi.org/10.23876/j.krcp.18.0118 |
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author | Lee, Changhyun Yun, Hae-Ryong Joo, Young Su Lee, Sangmi Kim, Joohwan Nam, Ki Heon Jhee, Jong Hyun Park, Jung Tak Yoo, Tae-Hyun Kang, Shin-Wook Han, Seung Hyeok |
author_facet | Lee, Changhyun Yun, Hae-Ryong Joo, Young Su Lee, Sangmi Kim, Joohwan Nam, Ki Heon Jhee, Jong Hyun Park, Jung Tak Yoo, Tae-Hyun Kang, Shin-Wook Han, Seung Hyeok |
author_sort | Lee, Changhyun |
collection | PubMed |
description | BACKGROUND: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. METHODS: This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low- (< 10%), intermediate- (10–20%), and high- (> 20%) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m(2)). RESULTS: During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3%), 217 (10.8%), and 205 (16.9%) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high- and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197–3.255) and 1.734 (95% CI, 1.447–2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. CONCLUSION: The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function. |
format | Online Article Text |
id | pubmed-6481968 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Society of Nephrology |
record_format | MEDLINE/PubMed |
spelling | pubmed-64819682019-05-07 Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study Lee, Changhyun Yun, Hae-Ryong Joo, Young Su Lee, Sangmi Kim, Joohwan Nam, Ki Heon Jhee, Jong Hyun Park, Jung Tak Yoo, Tae-Hyun Kang, Shin-Wook Han, Seung Hyeok Kidney Res Clin Pract Original Article BACKGROUND: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. METHODS: This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low- (< 10%), intermediate- (10–20%), and high- (> 20%) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m(2)). RESULTS: During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3%), 217 (10.8%), and 205 (16.9%) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high- and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197–3.255) and 1.734 (95% CI, 1.447–2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. CONCLUSION: The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function. Korean Society of Nephrology 2019-03 2019-03-31 /pmc/articles/PMC6481968/ /pubmed/30897893 http://dx.doi.org/10.23876/j.krcp.18.0118 Text en Copyright © 2019 by The Korean Society of Nephrology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Lee, Changhyun Yun, Hae-Ryong Joo, Young Su Lee, Sangmi Kim, Joohwan Nam, Ki Heon Jhee, Jong Hyun Park, Jung Tak Yoo, Tae-Hyun Kang, Shin-Wook Han, Seung Hyeok Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
title | Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
title_full | Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
title_fullStr | Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
title_full_unstemmed | Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
title_short | Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study |
title_sort | framingham risk score and risk of incident chronic kidney disease: a community-based prospective cohort study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481968/ https://www.ncbi.nlm.nih.gov/pubmed/30897893 http://dx.doi.org/10.23876/j.krcp.18.0118 |
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