Pharmacokinetics, Safety, and Efficacy of an Allometric Miltefosine Regimen for the Treatment of Visceral Leishmaniasis in Eastern African Children: An Open-label, Phase II Clinical Trial

BACKGROUND: Convenient, safe, and effective treatments for visceral leishmaniasis in Eastern African children are lacking. Miltefosine, the only oral treatment, failed to achieve adequate efficacy, particularly in children, in whom linear dosing (2.5 mg/kg/day for 28 days) resulted in a 59% cure rat...

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Detalles Bibliográficos
Autores principales: Mbui, Jane, Olobo, Joseph, Omollo, Raymond, Solomos, Alexandra, Kip, Anke E, Kirigi, George, Sagaki, Patrick, Kimutai, Robert, Were, Lilian, Omollo, Truphosa, Egondi, Thaddaeus W, Wasunna, Monique, Alvar, Jorge, Dorlo, Thomas P C, Alves, Fabiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Articles and Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6481997/
https://www.ncbi.nlm.nih.gov/pubmed/30188978
http://dx.doi.org/10.1093/cid/ciy747

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