RUNX represses Pmp22 to drive neurofibromagenesis

Patients with neurofibromatosis type 1 (NF1) are predisposed to develop neurofibromas, but the underlying molecular mechanisms of neurofibromagenesis are not fully understood. We showed dual genetic deletion of Runx1 and Runx3 in Schwann cells (SCs) and SC precursors delayed neurofibromagenesis and...

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Detalles Bibliográficos
Autores principales: Hall, Ashley, Choi, Kwangmin, Liu, Wei, Rose, Jonathan, Zhao, Chuntao, Yu, Yanan, Na, Youjin, Cai, Yuqi, Coover, Robert A., Lin, Yi, Dombi, Eva, Kim, MiOk, Levanon, Ditsa, Groner, Yoram, Boscolo, Elisa, Pan, Dao, Liu, P. Paul, Lu, Q. Richard, Ratner, Nancy, Huang, Gang, Wu, Jianqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482019/
https://www.ncbi.nlm.nih.gov/pubmed/31032403
http://dx.doi.org/10.1126/sciadv.aau8389

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