Naturally occurring antibodies isolated from PD patients inhibit synuclein seeding in vitro and recognize Lewy pathology

Deposition of α-synuclein into Lewy bodies and Lewy neurites is the hallmark of Parkinson’s disease (PD). It is hypothesized that α-synuclein pathology spreads by a “prion-like” mechanism (i.e., by seeded aggregation or templated misfolding). Therefore, various extracellular α-synuclein conformers a...

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Detalles Bibliográficos
Autores principales: Li, Xinyi, Koudstaal, Wouter, Fletcher, Lauren, Costa, Martha, van Winsen, Margot, Siregar, Berdien, Inganäs, Hanna, Kim, Julie, Keogh, Elissa, Macedo, Jeremy, Holland, Trevin, Perry, Stuart, Bard, Frederique, Hoozemans, Jeroen J., Goudsmit, Jaap, Apetri, Adrian, Pascual, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482120/
https://www.ncbi.nlm.nih.gov/pubmed/30805666
http://dx.doi.org/10.1007/s00401-019-01974-5

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