Fragment-based screening identifies inhibitors of ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system

Type IV secretion systems are multiprotein complexes that mediate the translocation of macromolecules across the bacterial cell envelope. In Helicobacter pylori a type IV secretion system encoded by the cag pathogenicity island encodes 27 proteins and most are essential for virulence. We here presen...

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Detalles Bibliográficos
Autores principales: Arya, Tarun, Oudouhou, Flore, Casu, Bastien, Bessette, Benoit, Sygusch, Jurgen, Baron, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482174/
https://www.ncbi.nlm.nih.gov/pubmed/31019200
http://dx.doi.org/10.1038/s41598-019-42876-6

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