SMN deficiency causes pain hypersensitivity in a mild SMA mouse model through enhancing excitability of nociceptive dorsal root ganglion neurons

Spinal muscular atrophy (SMA) is a devastating motor neuron degeneration disease caused by a deficiency of the SMN protein. Majority of patients also suffer from chronic pain. However, the pathogenesis of pain in the context of SMA has never been explored. In this study, using various pain tests, we...

Descripción completa

Detalles Bibliográficos
Autores principales: Qu, Ruobing, Yao, Fuping, Zhang, Xiaomin, Gao, Yuan, Liu, Tong, Hua, Yimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482187/
https://www.ncbi.nlm.nih.gov/pubmed/31019235
http://dx.doi.org/10.1038/s41598-019-43053-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482187/
https://www.ncbi.nlm.nih.gov/pubmed/31019235
http://dx.doi.org/10.1038/s41598-019-43053-5

Ejemplares similares