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Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species – Support for the Community Concept

Avian influenza A viruses (AIVs) have a broad host range, but are most intimately associated with waterfowl (Anseriformes) and, in the case of the H13 and H16 subtypes, gulls (Charadriiformes). Host associations are multifactorial, but a key factor is the ability of the virus to bind host cell recep...

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Autores principales: Eriksson, Per, Lindskog, Cecilia, Lorente-Leal, Victor, Waldenström, Jonas, González-Acuna, Daniel, Järhult, Josef D., Lundkvist, Åke, Olsen, Björn, Jourdain, Elsa, Ellström, Patrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482220/
https://www.ncbi.nlm.nih.gov/pubmed/31057520
http://dx.doi.org/10.3389/fmicb.2019.00815
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author Eriksson, Per
Lindskog, Cecilia
Lorente-Leal, Victor
Waldenström, Jonas
González-Acuna, Daniel
Järhult, Josef D.
Lundkvist, Åke
Olsen, Björn
Jourdain, Elsa
Ellström, Patrik
author_facet Eriksson, Per
Lindskog, Cecilia
Lorente-Leal, Victor
Waldenström, Jonas
González-Acuna, Daniel
Järhult, Josef D.
Lundkvist, Åke
Olsen, Björn
Jourdain, Elsa
Ellström, Patrik
author_sort Eriksson, Per
collection PubMed
description Avian influenza A viruses (AIVs) have a broad host range, but are most intimately associated with waterfowl (Anseriformes) and, in the case of the H13 and H16 subtypes, gulls (Charadriiformes). Host associations are multifactorial, but a key factor is the ability of the virus to bind host cell receptors and thereby initiate infection. The current study aims at investigating the tissue attachment pattern of a panel of AIVs, comprising H3N2, H6N1, H12N5, and H16N3, to avian trachea and colon tissue samples obtained from host species of different orders. Virus attachment was not restricted to the bird species or order from which the virus was isolated. Instead, extensive virus attachment was observed to several distantly related avian species. In general, more virus attachment and receptor expression were observed in trachea than in colon samples. Additionally, a human seasonal H3N2 virus was studied. Unlike the studied AIVs, this virus mainly attached to tracheae from Charadriiformes and a very limited set of avian cola. In conclusion, the reported results highlight the importance of AIV attachment to trachea in many avian species. Finally, the importance of chickens and mallards in AIVs dynamics was illustrated by the abundant AIV attachment observed.
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spelling pubmed-64822202019-05-03 Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species – Support for the Community Concept Eriksson, Per Lindskog, Cecilia Lorente-Leal, Victor Waldenström, Jonas González-Acuna, Daniel Järhult, Josef D. Lundkvist, Åke Olsen, Björn Jourdain, Elsa Ellström, Patrik Front Microbiol Microbiology Avian influenza A viruses (AIVs) have a broad host range, but are most intimately associated with waterfowl (Anseriformes) and, in the case of the H13 and H16 subtypes, gulls (Charadriiformes). Host associations are multifactorial, but a key factor is the ability of the virus to bind host cell receptors and thereby initiate infection. The current study aims at investigating the tissue attachment pattern of a panel of AIVs, comprising H3N2, H6N1, H12N5, and H16N3, to avian trachea and colon tissue samples obtained from host species of different orders. Virus attachment was not restricted to the bird species or order from which the virus was isolated. Instead, extensive virus attachment was observed to several distantly related avian species. In general, more virus attachment and receptor expression were observed in trachea than in colon samples. Additionally, a human seasonal H3N2 virus was studied. Unlike the studied AIVs, this virus mainly attached to tracheae from Charadriiformes and a very limited set of avian cola. In conclusion, the reported results highlight the importance of AIV attachment to trachea in many avian species. Finally, the importance of chickens and mallards in AIVs dynamics was illustrated by the abundant AIV attachment observed. Frontiers Media S.A. 2019-04-18 /pmc/articles/PMC6482220/ /pubmed/31057520 http://dx.doi.org/10.3389/fmicb.2019.00815 Text en Copyright © 2019 Eriksson, Lindskog, Lorente-Leal, Waldenström, González-Acuna, Järhult, Lundkvist, Olsen, Jourdain and Ellström. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Eriksson, Per
Lindskog, Cecilia
Lorente-Leal, Victor
Waldenström, Jonas
González-Acuna, Daniel
Järhult, Josef D.
Lundkvist, Åke
Olsen, Björn
Jourdain, Elsa
Ellström, Patrik
Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species – Support for the Community Concept
title Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species – Support for the Community Concept
title_full Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species – Support for the Community Concept
title_fullStr Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species – Support for the Community Concept
title_full_unstemmed Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species – Support for the Community Concept
title_short Attachment Patterns of Human and Avian Influenza Viruses to Trachea and Colon of 26 Bird Species – Support for the Community Concept
title_sort attachment patterns of human and avian influenza viruses to trachea and colon of 26 bird species – support for the community concept
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482220/
https://www.ncbi.nlm.nih.gov/pubmed/31057520
http://dx.doi.org/10.3389/fmicb.2019.00815
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