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Inhibition of the Interaction Between Group I Metabotropic Glutamate Receptors and PDZ-Domain Proteins Prevents Hippocampal Long-Term Depression, but Not Long-Term Potentiation
The group I metabotropic glutamate (mGlu) receptor subtypes, mGlu1 and mGlu5, strongly regulate hippocampal synaptic plasticity. Both harbor PSD-95/discs-large/ZO-1 (PDZ) motifs at their extreme carboxyl terminals, which allow interaction with the PDZ domain of Tamalin, regulate the cell surface exp...
Autores principales: | Neyman, Sergey, Braunewell, Karl-Heinz, O’Connell, Kara E., Dev, Kumlesh K., Manahan-Vaughan, Denise |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482240/ https://www.ncbi.nlm.nih.gov/pubmed/31057390 http://dx.doi.org/10.3389/fnsyn.2019.00013 |
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