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Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses

Over the last decade, there has been significant advances in the understanding of the cross-talk between metabolism and immune responses. It is now evident that immune cell effector function strongly depends on the metabolic pathway in which cells are engaged in at a particular point in time, the ac...

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Autores principales: Moreno-Altamirano, María Maximina B., Kolstoe, Simon E., Sánchez-García, Francisco Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482253/
https://www.ncbi.nlm.nih.gov/pubmed/31058096
http://dx.doi.org/10.3389/fcimb.2019.00095
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author Moreno-Altamirano, María Maximina B.
Kolstoe, Simon E.
Sánchez-García, Francisco Javier
author_facet Moreno-Altamirano, María Maximina B.
Kolstoe, Simon E.
Sánchez-García, Francisco Javier
author_sort Moreno-Altamirano, María Maximina B.
collection PubMed
description Over the last decade, there has been significant advances in the understanding of the cross-talk between metabolism and immune responses. It is now evident that immune cell effector function strongly depends on the metabolic pathway in which cells are engaged in at a particular point in time, the activation conditions, and the cell microenvironment. It is also clear that some metabolic intermediates have signaling as well as effector properties and, hence, topics such as immunometabolism, metabolic reprograming, and metabolic symbiosis (among others) have emerged. Viruses completely rely on their host's cell energy and molecular machinery to enter, multiply, and exit for a new round of infection. This review explores how viruses mimic, exploit or interfere with host cell metabolic pathways and how, in doing so, they may evade immune responses. It offers a brief outline of key metabolic pathways, mitochondrial function and metabolism-related signaling pathways, followed by examples of the mechanisms by which several viral proteins regulate host cell metabolic activity.
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spelling pubmed-64822532019-05-03 Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses Moreno-Altamirano, María Maximina B. Kolstoe, Simon E. Sánchez-García, Francisco Javier Front Cell Infect Microbiol Cellular and Infection Microbiology Over the last decade, there has been significant advances in the understanding of the cross-talk between metabolism and immune responses. It is now evident that immune cell effector function strongly depends on the metabolic pathway in which cells are engaged in at a particular point in time, the activation conditions, and the cell microenvironment. It is also clear that some metabolic intermediates have signaling as well as effector properties and, hence, topics such as immunometabolism, metabolic reprograming, and metabolic symbiosis (among others) have emerged. Viruses completely rely on their host's cell energy and molecular machinery to enter, multiply, and exit for a new round of infection. This review explores how viruses mimic, exploit or interfere with host cell metabolic pathways and how, in doing so, they may evade immune responses. It offers a brief outline of key metabolic pathways, mitochondrial function and metabolism-related signaling pathways, followed by examples of the mechanisms by which several viral proteins regulate host cell metabolic activity. Frontiers Media S.A. 2019-04-18 /pmc/articles/PMC6482253/ /pubmed/31058096 http://dx.doi.org/10.3389/fcimb.2019.00095 Text en Copyright © 2019 Moreno-Altamirano, Kolstoe and Sánchez-García. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Moreno-Altamirano, María Maximina B.
Kolstoe, Simon E.
Sánchez-García, Francisco Javier
Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
title Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
title_full Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
title_fullStr Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
title_full_unstemmed Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
title_short Virus Control of Cell Metabolism for Replication and Evasion of Host Immune Responses
title_sort virus control of cell metabolism for replication and evasion of host immune responses
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482253/
https://www.ncbi.nlm.nih.gov/pubmed/31058096
http://dx.doi.org/10.3389/fcimb.2019.00095
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