P-TEFb Activation by RBM7 Shapes a Pro-survival Transcriptional Response to Genotoxic Stress

DNA damage response (DDR) involves dramatic transcriptional alterations, the mechanisms of which remain ill defined. Here, we show that following genotoxic stress, the RNA-binding motif protein 7 (RBM7) stimulates RNA polymerase II (Pol II) transcription and promotes cell viability by activating the...

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Detalles Bibliográficos
Autores principales: Bugai, Andrii, Quaresma, Alexandre J.C., Friedel, Caroline C., Lenasi, Tina, Düster, Robert, Sibley, Christopher R., Fujinaga, Koh, Kukanja, Petra, Hennig, Thomas, Blasius, Melanie, Geyer, Matthias, Ule, Jernej, Dölken, Lars, Barborič, Matjaž
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482433/
https://www.ncbi.nlm.nih.gov/pubmed/30824372
http://dx.doi.org/10.1016/j.molcel.2019.01.033

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