Cargando…

Granular cell tumor presenting as an intraocular mass: a case report

BACKGROUND: Granular cell tumor (GCT) can arise in any location in the body and present as a solitary, slow-growing, painless mass. However, GCT rarely affects the orbit. We report a Chinese girl who presented with an intraocular mass, and in whom a biopsy led to a diagnosis of GCT. CASE PRESENTATIO...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jingyuan, Ren, Xinyu, Chen, Youxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482534/
https://www.ncbi.nlm.nih.gov/pubmed/31023279
http://dx.doi.org/10.1186/s12886-019-1102-5
_version_ 1783413901582401536
author Yang, Jingyuan
Ren, Xinyu
Chen, Youxin
author_facet Yang, Jingyuan
Ren, Xinyu
Chen, Youxin
author_sort Yang, Jingyuan
collection PubMed
description BACKGROUND: Granular cell tumor (GCT) can arise in any location in the body and present as a solitary, slow-growing, painless mass. However, GCT rarely affects the orbit. We report a Chinese girl who presented with an intraocular mass, and in whom a biopsy led to a diagnosis of GCT. CASE PRESENTATION: A 5-year-old Chinese girl exhibited exotropia in her right eye for 2 years and had been losing her vision for 6 months. The visual acuity in the right eye revealed no light perception. A fundus examination showed a large, yellowish-white, elevated, subretinal mass lesion in front of and inferior to the disc, with hemi-inferior-quadrant retinal detachment. The retina was greyish-yellow with scattered yellow spots. A vitrectomy with neoplasm resection was performed. A histopathologic examination revealed a GCT. The tumor cells were positive for CD68, NSE, S-100, and CD163 expression but negative for GFAP, Syn, and CD123 expression. The Ki-67 index was 1%. The right eye remained stable with visual acuity of no light perception at a 2-years follow-up. CONCLUSION: Intraocular GCT can present as a yellow-white solid mass with no calcification. Although intraocular GCT is very rare, it can lead to devastating visual loss. Intraocular GCT should be kept in mind and considered in clinical practice.
format Online
Article
Text
id pubmed-6482534
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-64825342019-05-02 Granular cell tumor presenting as an intraocular mass: a case report Yang, Jingyuan Ren, Xinyu Chen, Youxin BMC Ophthalmol Case Report BACKGROUND: Granular cell tumor (GCT) can arise in any location in the body and present as a solitary, slow-growing, painless mass. However, GCT rarely affects the orbit. We report a Chinese girl who presented with an intraocular mass, and in whom a biopsy led to a diagnosis of GCT. CASE PRESENTATION: A 5-year-old Chinese girl exhibited exotropia in her right eye for 2 years and had been losing her vision for 6 months. The visual acuity in the right eye revealed no light perception. A fundus examination showed a large, yellowish-white, elevated, subretinal mass lesion in front of and inferior to the disc, with hemi-inferior-quadrant retinal detachment. The retina was greyish-yellow with scattered yellow spots. A vitrectomy with neoplasm resection was performed. A histopathologic examination revealed a GCT. The tumor cells were positive for CD68, NSE, S-100, and CD163 expression but negative for GFAP, Syn, and CD123 expression. The Ki-67 index was 1%. The right eye remained stable with visual acuity of no light perception at a 2-years follow-up. CONCLUSION: Intraocular GCT can present as a yellow-white solid mass with no calcification. Although intraocular GCT is very rare, it can lead to devastating visual loss. Intraocular GCT should be kept in mind and considered in clinical practice. BioMed Central 2019-04-25 /pmc/articles/PMC6482534/ /pubmed/31023279 http://dx.doi.org/10.1186/s12886-019-1102-5 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Yang, Jingyuan
Ren, Xinyu
Chen, Youxin
Granular cell tumor presenting as an intraocular mass: a case report
title Granular cell tumor presenting as an intraocular mass: a case report
title_full Granular cell tumor presenting as an intraocular mass: a case report
title_fullStr Granular cell tumor presenting as an intraocular mass: a case report
title_full_unstemmed Granular cell tumor presenting as an intraocular mass: a case report
title_short Granular cell tumor presenting as an intraocular mass: a case report
title_sort granular cell tumor presenting as an intraocular mass: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482534/
https://www.ncbi.nlm.nih.gov/pubmed/31023279
http://dx.doi.org/10.1186/s12886-019-1102-5
work_keys_str_mv AT yangjingyuan granularcelltumorpresentingasanintraocularmassacasereport
AT renxinyu granularcelltumorpresentingasanintraocularmassacasereport
AT chenyouxin granularcelltumorpresentingasanintraocularmassacasereport