DNA methylation, transcriptome and genetic copy number signatures of diffuse cerebral WHO grade II/III gliomas resolve cancer heterogeneity and development

BACKGROUND: Diffuse lower WHO grade II and III gliomas (LGG) are slowly progressing brain tumors, many of which eventually transform into a more aggressive type. LGG is characterized by widespread genetic and transcriptional heterogeneity, yet little is known about the heterogeneity of the DNA methy...

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Detalles Bibliográficos
Autores principales: Binder, H., Willscher, E., Loeffler-Wirth, H., Hopp, L., Jones, D. T. W., Pfister, S. M., Kreuz, M., Gramatzki, D., Fortenbacher, E., Hentschel, B., Tatagiba, M., Herrlinger, U., Vatter, H., Matschke, J., Westphal, M., Krex, D., Schackert, G., Tonn, J. C., Schlegel, U., Steiger, H.-J., Wick, W., Weber, R. G., Weller, M., Loeffler, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482573/
https://www.ncbi.nlm.nih.gov/pubmed/31023364
http://dx.doi.org/10.1186/s40478-019-0704-8

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