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Debate: Should statin be used in patients with heart failure?

Statins reduce mortality of patients with coronary artery disease (CAD). However, by protocol, trials have excluded patients with chronic heart failure. Since the prevalent etiology of heart failure is CAD, preventing CAD may prevent heart failure progression. Statins may have other beneficial effec...

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Detalles Bibliográficos
Autor principal: Pietro Maggioni, Aldo
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64827/
https://www.ncbi.nlm.nih.gov/pubmed/11806811
http://dx.doi.org/10.1186/cvm-2-6-266
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author Pietro Maggioni, Aldo
author_facet Pietro Maggioni, Aldo
author_sort Pietro Maggioni, Aldo
collection PubMed
description Statins reduce mortality of patients with coronary artery disease (CAD). However, by protocol, trials have excluded patients with chronic heart failure. Since the prevalent etiology of heart failure is CAD, preventing CAD may prevent heart failure progression. Statins may have other beneficial effects besides cholesterol lowering, such as anti-inflammatory properties and improvement of endothelial function. On the contrary, high levels of cholesterol can be beneficial in heart failure patients on the basis of the ability of serum lipoproteins to modulate inflammatory response. Furthermore, statins affecting mitochondrial function can have a deleterious effect on skeletal or cardiac muscles. Despite all these conflicting data, there is no evidence from trials on the effects of statins in patients with heart failure. For this reason, the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI) investigators planned a controlled trial testing the effect of statins in patients with heart failure of different etiology.
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spelling pubmed-648272002-01-25 Debate: Should statin be used in patients with heart failure? Pietro Maggioni, Aldo Curr Control Trials Cardiovasc Med Commentary Statins reduce mortality of patients with coronary artery disease (CAD). However, by protocol, trials have excluded patients with chronic heart failure. Since the prevalent etiology of heart failure is CAD, preventing CAD may prevent heart failure progression. Statins may have other beneficial effects besides cholesterol lowering, such as anti-inflammatory properties and improvement of endothelial function. On the contrary, high levels of cholesterol can be beneficial in heart failure patients on the basis of the ability of serum lipoproteins to modulate inflammatory response. Furthermore, statins affecting mitochondrial function can have a deleterious effect on skeletal or cardiac muscles. Despite all these conflicting data, there is no evidence from trials on the effects of statins in patients with heart failure. For this reason, the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI) investigators planned a controlled trial testing the effect of statins in patients with heart failure of different etiology. BioMed Central 2001 2001-11-27 /pmc/articles/PMC64827/ /pubmed/11806811 http://dx.doi.org/10.1186/cvm-2-6-266 Text en Copyright © 2001 BioMed Central Ltd
spellingShingle Commentary
Pietro Maggioni, Aldo
Debate: Should statin be used in patients with heart failure?
title Debate: Should statin be used in patients with heart failure?
title_full Debate: Should statin be used in patients with heart failure?
title_fullStr Debate: Should statin be used in patients with heart failure?
title_full_unstemmed Debate: Should statin be used in patients with heart failure?
title_short Debate: Should statin be used in patients with heart failure?
title_sort debate: should statin be used in patients with heart failure?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64827/
https://www.ncbi.nlm.nih.gov/pubmed/11806811
http://dx.doi.org/10.1186/cvm-2-6-266
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